Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1993-12-08
1998-01-06
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
514 59, 514 54, A61K 4736
Patent
active
057051780
ABSTRACT:
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.
REFERENCES:
patent: 2715091 (1955-08-01), Ricketts et al.
patent: 3487150 (1969-12-01), Barnes et al.
patent: 3627872 (1971-12-01), Parkinson
patent: 3632754 (1972-01-01), Balassa
patent: 3847155 (1974-11-01), Bernaola
patent: 3886947 (1975-06-01), Sawyer
patent: 3914413 (1975-10-01), Balassa
patent: 4021544 (1977-05-01), Nair et al.
patent: 4066829 (1978-01-01), Nair et al.
patent: 4141973 (1979-02-01), Balazs
patent: 4207312 (1980-06-01), Fujii et al.
patent: 4225580 (1980-09-01), Rothman et al.
patent: 4232007 (1980-11-01), Kajihara et al.
patent: 4271084 (1981-06-01), Ishikawa et al.
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4315002 (1982-02-01), Maurer
patent: 4321273 (1982-03-01), Ishikawa et al.
patent: 4350629 (1982-09-01), Yannas et al.
patent: 4428939 (1984-01-01), Prockop
patent: 4448718 (1984-05-01), Yannas et al.
patent: 4465666 (1984-08-01), Lukas et al.
patent: 4485088 (1984-11-01), Chvapil
patent: 4496397 (1985-01-01), Waite
patent: 4536496 (1985-08-01), Shimizu et al.
patent: 4537767 (1985-08-01), Rothman et al.
patent: 4538603 (1985-09-01), Pawelchak et al.
patent: 4585585 (1986-04-01), Waite
patent: 4592864 (1986-06-01), Miyata et al.
patent: 4609640 (1986-09-01), Morishita et al.
patent: 4613502 (1986-09-01), Turkova et al.
patent: 4618490 (1986-10-01), De Marco
patent: 4625016 (1986-11-01), Prockop
patent: 4640912 (1987-02-01), Hausman
patent: 4659572 (1987-04-01), Murray
patent: 4672031 (1987-06-01), Prockop
patent: 4687740 (1987-08-01), Waite
patent: 4692435 (1987-09-01), Lormeau et al.
patent: 4703108 (1987-10-01), Silver et al.
patent: 4710493 (1987-12-01), Landsberger
patent: 4713446 (1987-12-01), DeVore et al.
patent: 4716224 (1987-12-01), Sakurai et al.
patent: 4728642 (1988-03-01), Pawelchak et al.
patent: 4745098 (1988-05-01), Michaeli
patent: 4747848 (1988-05-01), Maini
patent: 4755379 (1988-07-01), Jozefonvicz et al.
patent: 4760131 (1988-07-01), Sundsmo et al.
patent: 4773408 (1988-09-01), Cilento et al.
patent: 4773409 (1988-09-01), Cilento et al.
patent: 4778768 (1988-10-01), Heinegard et al.
patent: 4783447 (1988-11-01), Del Bono et al.
patent: 4788200 (1988-11-01), Niwa et al.
patent: 4793336 (1988-12-01), Wang
patent: 4801619 (1989-01-01), Lindblad
patent: 4803075 (1989-02-01), Wallace et al.
patent: 4804652 (1989-02-01), Lormeau et al.
patent: 4808570 (1989-02-01), Michaeli
patent: 4820303 (1989-04-01), Brauman
patent: 4829000 (1989-05-01), Kleinman et al.
patent: 4837024 (1989-06-01), Michaeli
patent: 4840941 (1989-06-01), Ueno et al.
patent: 4863907 (1989-09-01), Sakurai et al.
patent: 4865846 (1989-09-01), Kaufman
patent: 4880429 (1989-11-01), Stone
patent: 4882148 (1989-11-01), Pinchuk
patent: 4886787 (1989-12-01), de Belder et al.
patent: 4908350 (1990-03-01), Kramer et al.
patent: 4912093 (1990-03-01), Michaeli
patent: 4925678 (1990-05-01), Ranney
patent: 4925924 (1990-05-01), Silver et al.
patent: 4927806 (1990-05-01), Kramer et al.
patent: 4943630 (1990-07-01), Jacquinet et al.
patent: 4945086 (1990-07-01), Benitz et al.
patent: 4992533 (1991-02-01), Kobayashi et al.
patent: 5008253 (1991-04-01), Casu et al.
patent: 5013724 (1991-05-01), Petitou et al.
patent: 5015677 (1991-05-01), Benedict et al.
patent: 5049403 (1991-09-01), Larm et al.
patent: 5055301 (1991-10-01), Voigt et al.
patent: 5089479 (1992-02-01), Krivan et al.
patent: 5108759 (1992-04-01), Ranney
patent: 5112608 (1992-05-01), Scott et al.
patent: 5120322 (1992-06-01), Davis et al.
patent: 5126440 (1992-06-01), Paris et al.
patent: 5135920 (1992-08-01), Kanamaru et al.
patent: 5152978 (1992-10-01), Baba et al.
patent: 5153181 (1992-10-01), Diringer et al.
patent: 5196185 (1993-03-01), Silver et al.
patent: 5196196 (1993-03-01), Scott et al.
patent: 5213898 (1993-05-01), Larm et al.
patent: 5227372 (1993-07-01), Folkman
patent: 5262403 (1993-11-01), Nicolson
Abrams, et al., 1989, Oral Dextran Sulfate (UA001) In The Treatment Of The Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex, Annuals Int. Med., 110: 183-188.
Adler, 1988, Inhibition Of Rat Glomerular Visceral Epithelial Cell Growth By Heparin, Am. J. Physio. 255: F781-F786.
Akeson and Warren, 1986, "PC12 adhesion and neurite formation on selected substrates are inhibited by some glycosaminoglycans and a fibronectin-derived tetrapeptide," Exp. Cell. Res. 162:347-362.
American Heritage Dictionary, 1982, 2d College Ed., Houghton Mifflin Co., pp.962, 1128.
Amiel, et al., 1985, Value Of Hyaluronic Acid In The Prevention Of Contracture Formation, Clinical Orthopaedics and Related Research, No. 196: 306-311.
Amiel, et al., 1985, Value Of Hyaluronic Acid In The Prevention Of Contracture Formation, Clinical Orthopaedics and Related Research, No. 196:306-311.
Araki et al., 1982, "The effects of dextran sulfate on the treatment of diabetic retinopathy," Rin-Gan (Japanese J. Clin. Opthamol.) 36(2):97-103 (Japanese article, with English translation of entire article).
Austin and Walker, 1976, "Flexor tendon healing and adhesion formation after Sterispon wrapping: a study in the rabbit," Injury 10:211-216.
Baier, et al., 1984, Surface Properties Determine Bioadhesive Outcomes: Methods And Results, Journal of Biomedical Materials Research, 18: 337-355.
Balazs and Darzynkiewicz, 1972, The Effect Of Hyaluronic Acid On Fibroblasts, Mononuclear Phagocytes And Lymphocytes, in Biology of Fibroblast (Kulonen and Pikkarainen, eds.) Academic Press: London and New York, pp.237-252.
Barrack and Hollenberg, 1981, Mitogenesis In Normal Human Fibroblasts By Polyinosinic-Polycytidylic Acid And Other Synthetic Acidic Polymers: Enhancement Of Action By Glucocorticoids, Journal of Cellular Physiology, 108: 445-454.
Bellavia, et al., 1987, Effects Of Dextran Sulphate On Lymphoblast Extravasation Into Inflammatory Skin Sites, Immunopharmacol., 13: 173-180.
Benoist et al., 1980, Postoperative Lumber Epiduro-Arachnoiditis: Diagnostic And Therapeutic Aspects, Spine, 5: 432-436.
Binor et al., 1984, "The effect of 32% dextran 70 (DEX), dexamethasone (DEC), Promethazine (PRO), and Ibuprofen (IBU) in preventing postoperative adhesions," Fertil. Steril. 41 (2 Suppl.):48S (Abstr. 110) (40th Ann. Meeting of the American Fertility Society, New Orleans, LA, Apr. 2-7, 1984).
Bremerskov, 1973, Nature New Biol., 246: 174.
Brennan et al., 1983, "Effect of proteoglycan produced by rat tumor cells on their adhesion to fibronectin-collagen substrata," Cancer Res. 43:4302-4307.
Brody, New Methods To Counter Serious Scarring, The New York Times, May 22, 1991, p. C10, column 1.
Brown, 1950, "Quinone tanning in the animal kingdom," Nature 165:275.
Burke, 1987, "Observations on the developoment and clinical use of artificial skin--an attempt to employ regeneration rather than scar formation in wound healing," Jap. J. Surg. 17:431-438.
Carbonetto, et al., 1983, Nerve Fiber Growth In Culture On Fibronectin, Collagen, And Glycosaminoglycan Substrates, The Journal of Neuroscience, 3: 2324-2335.
Cauchoix and Girard, 1978, Repeat Surgery After Disc Excision, Spine 3: 256-259.
Chiu, et al., 1987, Effect Of Dextran Sulfate On The Growth of Cultured Fibroblasts Derived From Normal Human Skin and Keloid Lesions, J. Formosan Med. Assoc. 86: 264-270.
Cies
Coker, III George T.
Frederickson Robert C. A.
Harel Adrian
Roufa Dikla
Gliatech Inc.
Kishore Gollamudi S.
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