Methods and compositions as protein kinase inhibitors

Details Methods and compositions as protein kinase inhibitors Methods and compositions as protein kinase inhibitors

2007-03-13

2007-03-13

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S326000, C544S328000, C544S333000

Reexamination Certificate

active

10956412

ABSTRACT:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.

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West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
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Fabbro et al. Pharmacology & therapeutics 93, 79-98, 2002.

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