Methods and artificial genes for antagonizing the function of an

Details Methods and artificial genes for antagonizing the function of an Methods and artificial genes for antagonizing the function of an

1984-04-13

1988-04-26

Hazel, Blondel

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435320, 435 91, 536 27, C12N 1500, C07H 2104, C12P 1934

Patent

active

047404639

ABSTRACT:
A method of antagonizing the effects of an oncogene by constructing an artificial gene which antagonizes the function of the oncogene is described herein. In one embodiment, the artificial gene comprises a transcriptional promoter segment, an inverted oncogene segment, and a polyadenylation segment.

REFERENCES:
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Chemical Abstracts, vol. 93, Abstract No. 3727y, 1980.
Chemical Abstracts, vol. 99, Abstract No. 116988b, 1983.
Chemical Abstracts, vol. 93, Abstract No. 234901s, 1980.
McCoy M. S., C. I. Bargmann and R. A. Weinberg, Human Colon Carcinoma Ki-ras2 Oncogene and Its Corresponding Proto-Oncogene, Molecular and Cellular Biology, 4:1577-1582, (1984).
Mizuno, T., M. Y. Chore and M. Inouye, A Unique Mechanism Regulating Gene Expression: Translational Inhibition by a Complementary RNA transcript (micRNA), Proceedings of the National Academy of Sciences, USA, 81: 1966-1970, (1984).
Izant, J. G. and H. Weintraub, Inhibition of Thymidine Kinase Gene Expression by Anti-sense RNA: a Molecular Approach to Genetic Analysis, Cell, 36:1007-1015, (1984).

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