Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues
Patent
1997-06-13
1999-08-03
Diamond, Alan
Bleaching and dyeing; fluid treatment and chemical modification
Treatment of hides, skins, feathers and animal tissues
Internal tissues
623 1, 623 2, 623 11, 623 12, 422 1, 422 38, A61L 204, A61L 1700, A61L 2700
Patent
active
059319690
ABSTRACT:
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with a treatment solution, inducing relative tissue/solution movement, and heating the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.
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Sealed Information Submission Under MPEP .sctn. 724 (Date Unknown).
Girardot, et. al, 1995, "Role of glutaraldehyde in calcification of porcine heart valves: Comparing cusp and wall", Journal of Biomedical Materials Research, vol. 29, 793-801 (Month Unknown).
Carpentier Alain F.
Carpentier Sophie
Packham Victor S.
Quintero Lillian J.
Schreck Stefan G.
Baxter International Inc.
Cumberbatch Guy L.
Diamond Alan
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