Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...
Reexamination Certificate
2011-03-29
2011-03-29
Seidleck, James (Department: 1765)
Plastic and nonmetallic article shaping or treating: processes
Encapsulating normally liquid material
Liquid encapsulation utilizing an emulsion or dispersion to...
C428S402200, C428S402210, C428S402240
Reexamination Certificate
active
07914714
ABSTRACT:
The methods of the invention employ electrostatic atomization to form a compound droplet of at least two miscible fluids. The compound droplet comprises a core of a first fluid and a layer of a second fluid completely surrounding the core. The first fluid contains the agent to be encapsulated and the second fluid contains an encapsulating agent. The first and second liquids are miscible. The encapsulated droplets can contain a variety of materials including, but not limited to, polynucleotides such as DNA and RNA, proteins, bioactive agents or drugs, food, pesticides, herbicides, fragrances, antifoulants, dyes, oils, inks, cosmetics, catalysts, detergents, curing agents, flavors, fuels, metals, paints, photographic agents, biocides, pigments, plasticizers, propellants and the like and components thereof. The droplets can be encapsulated by a variety of materials, including, but not limited to, lipid bilayers and polymer shells. An additional complete or partial layer of a third fluid can be formed on the outside of the second fluid layer. The third fluid can contain a targeting or steric stabilizing agent.
REFERENCES:
patent: 2275154 (1940-07-01), Merrill et al.
patent: 2766478 (1951-10-01), Raley, Jr. et al.
patent: 3015128 (1962-01-01), Somerville, Jr.
patent: 3310612 (1965-03-01), Somerville, Jr.
patent: 3389194 (1968-06-01), Somerville
patent: 5122670 (1992-06-01), Mylchreest et al.
patent: 5393975 (1995-02-01), Hail et al.
patent: 6103271 (2000-08-01), Morrison et al.
patent: 6143211 (2000-11-01), Mathiowitz et al.
patent: 6234402 (2001-05-01), Ganan-Calvo
patent: 6399362 (2002-06-01), Pui et al.
patent: 6405936 (2002-06-01), Ganan-Calvo
patent: 6719933 (2004-04-01), Nakamura et al.
patent: 2002/0007869 (2002-01-01), Pui et al.
patent: 2003/0066969 (2003-04-01), De La Mora et al.
patent: 2004/0069632 (2004-04-01), Ripoll et al.
patent: WO 02/060275 (2002-08-01), None
patent: WO 02/060591 (2002-08-01), None
patent: WO 2004/103510 (2004-12-01), None
Allen et al. (Mar. 19, 2004) “Drug Delivery Systems: Entering the Mainstream,”Science303:1818-1822.
Bangham et al. (1965) “Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids,”J. Mol. Biol. 3:238-252.
De Juan et al. (1997) “Charge and Size Distributions of Electrospray Drops,”J. Colloid Int. Sci. 186:280-293.
Disher et al. (May 14, 1999) “Polymersomes: Tough Vesicles Made from Diblock Copolymers,”Science284:1143-1146.
Felgner et al. (Nov. 1987) “Lipofection—A Highly Efficient, Lipid-Mediated DNA Transfection Procedure,”Proc. Natl. Acad. Sci. USA84(21):7413-7417.
Ganan-Calvo, A.M. (Jan. 12, 1998) “Generation of Steady Liquid Microthreads and Micron-Sized Monodisperse Sprays in Gas Streams,”Phys. Rev. Lett. 80(2):285-288.
Ganan-Calvo, A.M. (1997) “On the Theory of Electrohydrodynamically Driven Capillary Jets,”J. Fluid Mechanics335:165-188.
Ganan-Calvo, A.M. (1999) “The Surface Charge in Electrospraying: its Nature and its Universal Scaling Laws,”J. Aerosol Sci. 30(7):863-872.
Gao et al. (1996) “Protein of Cationic Liposome-Mediated Gene Delivery by Polycations,”Biochem. 35:1027-1036.
Gregoriadis, G. (1995) “Engineering Liposomes for Drug Delivery: Progress and Problems,”Tibtech13:527-537.
Hofland et al. (Jul. 1996) “Formation of Stable Cationic Lipid/DNA Complexes for Gene Transfer,”Proc. Natl. Acad. Sci. USA93(14):7305-7309.
International Search Report, Corresponding to International Application No. PCT/US04/15151, Mailed Oct. 28, 2005.
Lasic et al. (1995) “Transmembrane Gradient Driven Phrase Transactions within Vesicles: Lessons for Drug Delivery,”Biochim. Biophys. Acta1239:145-156.
Lengsford et al. (Jun. 2003) “Pulmonary Gene Delivery: Impact of Aerosolization Method on Bioactivity,”J. Aerosol Med. 16(2):196.
Lesney, M.S. (2001) “Going Cellular,”Modern Drud Discovery4(3):45-46,49,50.
Lopez-Herrera et al. (May 2003) “Coaxial Jets Generated from Electrified Taylor Cones. Scaling Laws,”J. Aerosol. Sci. 34(5):535-552.
Loscertales et al. (Mar. 1, 2002) “Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets,”Science295:1695-1698.
Nicolazzi et al. (Mar. 26, 2003) “Anionic Polyethyleneglycol Lipids Added to Cationic Lipoplexes Increase their Plasmatic Circulation Time,”J. Cont. Release88(3):429-443.
Regele et al. (Nov. 2002) “Effects of Capillary Spacing on EHD Spraying from an Array of Cone Jets,”J. Aerosol Sci. 33(11):1471-1479.
Rickard et al. (2002) “Experimental Study of a Hybrid Electrohydrodynamic, Air-Assisted Liquid Atomizer, SAE Document No. 2002-01-2754,” Presented at: SAE Powertrain & Fluid Systems Conference & Exhibition, Oct. 2002, San Diego, Ca, USA.
Rosell-Lompart et al. (1994) “Generation of Monodisoerse Droplets 0.3 to 4 μm in Diameter from Electrified Con-Jets of Highly Conducting and Viscous Liquids,”J. Aerosol. Sci. 25(6):1093-1119.
Semple et al. (2001) “Efficient Encapsulation of Antisense Oligonucleotides in Lipid Vesicles Using Ionizable Aminolipids: Formation of Novel Small Multimellar Vesicle Structures,”Biochim. Biophys. Acta1510:152-166.
Uchengbu et al. (1998) “Polymeric Chitosan Based Vesicles for Drug Delivery,”J. Pharm. Pharmacol. 50:453-458.
Uchengbu et al. (1998) “Polymeric Vesicles from Amino Acid Homopolymers,”Proc. Int. Symp. Control. Release Bioact. Mater. 25:186-187.
Uchegbu et al. (1999) “Parental Drug Delivery: 1,”Pharm. J. 263:309-318.
Yamaguchi et al. (Jun. 17, 2002) “Insulin-Loaded Biodegradable PLGA Microcapsules: Initial Bursat Release Controlled by Hydrophilic Additives,”J. Cont. Release81(3):235-249.
Chen et al. (2000) “A Novel Approach for Introducing Bio-Materials into Cells,”J. Nanoparticle Res. 2:133-139.
Mei et al. (Web Release Oct. 3, 2007) “Investigation of Compound Jet Electrospray: Particle Encapsulation,”Physics of Fluids19:103303.
Mei et al. (2008) “Operational Modes of Dual-Capillary Electrospraying and the Formation of the Stable Compound Cone-Jet Mod,”Aerosol Air Quality Res. 8(2):218-232.
Oliver et al. (May 2005) “Two Fluid VOF Simulation of Droplet Impact on a Liquid Pool,”ILASS Americas, 18thAnnual Conference on Liquid Atomization and Spray Systems, Irvine, CA.
Written Opinion, Corresponding to International Application PCT/US2004/015151, Mailed Oct. 28, 2005.
Anchordoquy Thomas J.
Brinkley Kelly
Jones Ryan
Lengsfeld Corinne
Greenlee Sullivan P.C.
Pourbohloul S. Camilla
Seidleck James
The Regents of the University of Colorado
LandOfFree
Methods and apparatus using electrostatic atomization to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and apparatus using electrostatic atomization to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and apparatus using electrostatic atomization to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2745135