Methods and apparatus for treating disease states using oxidized

Details Methods and apparatus for treating disease states using oxidized Methods and apparatus for treating disease states using oxidized

1990-10-04

1993-03-09

Yasko, John D.

Surgery

Blood drawn and replaced or treated and returned to body

604 49, 128898, A61M 3700

Patent

active

051922649

ABSTRACT:
The present invention relates to treating disease states in a living patient using oxidized lipoproteins, preferably low density peroxidized lipoproteins. Methods and apparatus are provided for preparing the oxidized lipoproteins. It has been discovered that diseased cells, characterized by an increased number of lipoprotein receptors or an enhanced ability to take up lipoproteins are more susceptible than healthy cells to the the cytotoxic effect of oxidized lipoproteins. Oxidized lipoproteins are used to treat disease states such as cancer, malaria and viral infections such as acquired immunodeficiency syndrome (AIDS). Proton and carbon-13 NMR spectroscopy is used to measure the degree and effect of treatment with oxidized lipoproteins.

REFERENCES:
patent: 2095388 (1937-10-01), Luther
patent: 3655700 (1972-04-01), Siddall
patent: 3959287 (1976-05-01), Goldstein
patent: 4126416 (1978-11-01), Sears
patent: 4226713 (1980-10-01), Goldberg
patent: 4472303 (1984-09-01), Tanihara
patent: 4544630 (1985-10-01), Ziegenhorn
patent: 4608347 (1986-08-01), Bernstam
patent: 4912092 (1990-03-01), Gruber
patent: 4933844 (1990-06-01), Otvos
patent: 4940055 (1990-07-01), Brown
Hore et al., "Solvent Suppression in Fortran . . . ," 55, J. of Mag. Res., 283-300 (1983).
Morel et al., "Low density lipoprotein cytotoxicity . . . ,"24, J. of Lipid Research, 1070 (1983).
Shulman et al., "NMR-Another Cancer . . . ," 322(14), New England J. Med., 1002-3 (1990).
Bell et al., "'H NMR Studies of human blood plasma," 219, FEB Letters, No. 1, 239-243 (Jul. 1987).
Hessler et al., "Lipoprotein oxidation and . . . ," 3(3), Arteriosclerosis, 215-222 (1983).
Christopherson, B. O., Biochem, Biophys, V. 164 (1), 35-46 and Abstract (1968).
Edelson, R., et al, N. Eng. J. of Med., V. 316, pp. 297-303, (1987). "Treatment of Cutaneous T-Cell Lymphoma by Extracorporeal Photochemotherapy".
Garner, C. W., Lipids, 19(11), 863-8 & Abstract 42042v (1984) "Peroxidation of free and esterified fatty acids by . . . ".
Hatzelmann, A., Eur. J. Biochem, V180(3), 527-333 & Abstract (1989), "Involvement of Glutathione Peroxidase Activity . . . ".
Lehninger, Chapter 11, Lipids, Lipoproteins & Membranes, "Lipoprotein Systems," p. 301 (1975).
Palladino, Michael et al, Jour. of Immunology, V. 138, pp. 4023-4032 "Characterization of the Antitumor Activities of Human . . . " 1987.
Pokorny, Jan et al, Chem. Abstracts, vol. 78, p. 178, 39712u "Origin & structure of dimeric fatty acids" (1973).
Semb, Henrik, et al, Jour. of Biolo. Chemistry, V. 262, n. 17 pp. 8390-8394, "Multiple Effect of TNF", Jun. 15, 1987.
Stryer, Lubert, W. H. Freemand & Co., N.Y., 3d Edition, 1975 and 1988, p. 560.
Chisolm, G., et al., "Lipoprotein Oxidation and Cyotoxicity: Effect of Probucol on Streptozotocin -Treated Rats.," (1988) pp. 20B-26B.
Kita, T. et al., "The Role of Oxidized Low Density Lipoproteins in the Pathogenesis of Atherosclerosis", Aug. 1990, pp. 122-127.
Kosugi, K., et al., "Toxicity of Oxidized Low-Density Lipoprotein to Cultured Fibroblast Is Selective for S-Phase of the Cell Cycle", 1987, pp. 311-320.
Hamilton T., et al., "Oxidized Low Density Lipoprotein Suppresses the Expression of Tumor Necrosis Factor-.alpha.mRNA in Stimulated Murine Peritoneal Macrophages,"Mar. 15, 1990, pp. 2343-2350.

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