Methods and apparatus for the generation of chemical libraries

Details Methods and apparatus for the generation of chemical libraries Methods and apparatus for the generation of chemical libraries

1996-09-18

1998-06-23

Warden, Jill

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing gas sample

422101, 422102, 422 63, 422129, B01L 300

Patent

active

057701571

ABSTRACT:
Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction chambers, and has fittings that facilitate robotic manipulation. The reaction chambers are preferably fitted with a frit. An s-shaped trap tube snaps into a fitting on the bottom of each reaction chamber. The trap tube runs into a drain tube. The reaction block is fitted with gas (preferably N.sub.2) lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station provides for secure registration of the reaction blocks, and provides for introduction of gases and liquids into the reaction blocks. An inert atmosphere in the reaction block is maintained by a top and (optional) bottom seal. A synthesis support may be introduced into each reaction chamber as a slurry, and the top septum fastened. A needle pipettes reagents from an array of reagent containers into the reaction chambers, and maintains the inert atmosphere. A locking reagent container rack keeps the containers securely in place.

REFERENCES:
patent: 4087248 (1978-05-01), Miles
patent: 4154795 (1979-05-01), Thorne
patent: 4304865 (1981-12-01), O'Brien et al.
patent: 4319841 (1982-03-01), Suovaniemi et al.
patent: 4483964 (1984-11-01), Urdea et al.
patent: 4517338 (1985-05-01), Urdea et al.
patent: 4567021 (1986-01-01), Sakagami
patent: 4659222 (1987-04-01), Ekholm
patent: 4746490 (1988-05-01), Saneii
patent: 4797259 (1989-01-01), Matkovich et al.
patent: 4830832 (1989-05-01), Arpagaus et al.
patent: 4931256 (1990-06-01), Mack et al.
patent: 4931402 (1990-06-01), Abplanalp
patent: 4948442 (1990-08-01), Manns
patent: 4948564 (1990-08-01), Root et al.
patent: 4952518 (1990-08-01), Johnson et al.
patent: 4956298 (1990-09-01), Diekmann
patent: 4970165 (1990-11-01), Uhrin
patent: 5039493 (1991-08-01), Oprandy
patent: 5048957 (1991-09-01), Berthold et al.
patent: 5108704 (1992-04-01), Bowers et al.
patent: 5114681 (1992-05-01), Bertoncini et al.
patent: 5122342 (1992-06-01), McCulloch et al.
patent: 5206171 (1993-04-01), Dillon et al.
patent: 5219528 (1993-06-01), Clark
patent: 5240680 (1993-08-01), Zuckermann et al.
patent: 5252296 (1993-10-01), Zuckermann et al.
patent: 5260028 (1993-11-01), Astle
patent: 5260872 (1993-11-01), Copeland et al.
patent: 5283039 (1994-02-01), Aysta
patent: 5306420 (1994-04-01), Bisconte
patent: 5306510 (1994-04-01), Meltzer
patent: 5324483 (1994-06-01), Cody et al.
patent: 5342581 (1994-08-01), Sanadi
patent: 5372945 (1994-12-01), Alchas et al.
patent: 5443791 (1995-08-01), Cathcart et al.
patent: 5512247 (1996-04-01), Bonacina et al.
patent: 5525300 (1996-06-01), Danssaert et al.
Catalog of Aldrich Chemical Company, Inc. 1992 pp. 1507, 1591, 1635, 1636, 1867, 1923 and 1929.
DeWitt, S.H., et al.; "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity; Proc. Natl. Acad. Sci. USA, vol. 90, pp. 6909-6913, Aug. 1993.

Affiliated with

Also associated with

Rating

Methods and apparatus for the generation of chemical libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and apparatus for the generation of chemical libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and apparatus for the generation of chemical libraries will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1392230