Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Patent
1998-04-07
1999-03-16
Redding, David A.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
4352841, 4352865, 600 36, 73790, 73807, 73818, 73843, 73846, 73847, C07C 0000, C12M 300
Patent
active
058829296
ABSTRACT:
Apparatus and methods are disclosed for maturing a biopolymer tissue construct in vitro prior to use as a replacement construct in vivo as, for example, a graft, implant, or prosthesis. The tissue is seeded with specific cells, exposed to a maturation fluid, such as a synovial-like fluid containing hyaluronic acid, and subjected to selected conditioning and maturation forces, which can include frictional forces, shear forces, and compressive pressure. The tissue is mounted on a first support element and a second surface applies a selected force to the tissue. This maturation process occurs within a maturation chamber. The resultant matured replacement tissue construct is intended to provide a replacement tissue that is more readily integrable in vivo to produce a more durable and functional replacement tissue.
REFERENCES:
patent: 5521087 (1996-05-01), Lee et al.
patent: 5700688 (1997-12-01), Lee et al.
patent: 5792603 (1998-08-01), Dunkelman et al.
D. Huang et al., "Mechanisms and Dynamics of Mechanical Strengthening in Ligament-Equivalent Fibroblast-Populated Collagen Matrices," Annals of Biomedical Engineering, vol. 21, pp. 289-305 (1993).
E. Bell, Tissue Engineering: Current Perspectives, Birkhauser, Boston, 1993 .
Bell Eugene
Fofonoff Timothy W.
Laurentano Anthony A.
Redding David A.
Tissue Engineering, Inc.
LandOfFree
Methods and apparatus for the conditioning of cartilage replacem does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and apparatus for the conditioning of cartilage replacem, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and apparatus for the conditioning of cartilage replacem will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-816799