Methods and apparatus for tailoring spectroscopic calibration mo

Radiant energy – Photocells; circuits and apparatus – Optical or pre-photocell system

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25033909, G01N 1506

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active

061570419

ABSTRACT:
A method and apparatus for non-invasively measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate subject-specific attributes, resulting in a calibration data set modeling within--subject physiological variation, sample location, insertion variations, and instrument variation. In a prediction phase, the prediction process is tailored for each target subject separately using a minimal number of spectral measurements from each subject.

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