Methods and apparatus for processing liquids

Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure

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436 43, 436 45, 422 64, 422 81, 422116, 422 681, G01N 3300

Patent

active

053169549

ABSTRACT:
Apparatus and methods for processing liquids are provided. The apparatus include open-ended, hollow reactor compartments which are detachably connected to receptor ends of tube systems. In preferred embodiments, a portion of the tube system is fixed to a rotor arm which can be rotated in a circle and moved up and down. Another portion of the tube system is coupled to a metering syringe which serves for drawing in or ejecting fluids into or from the reactor compartment and/or the tube system. A plurality of process stations such as bottles containing reagents or solvents can be arranged on a circular tray such that they can be accessed by the reactor compartment or by the receptor end if the reactor compartment has been detached from the tube system. The invention can be used, for example, for automatic protein sequencing, whereby the proteins to be sequenced are held in place by a matrix in the reactor compartment.

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Wada, et al., Review of Scientific Instruments, 1983, vol. 54, No. 11, pp. 1569-1572.
Kretz, et al., Hewlett-Packard Journal, 1984, 21-24.

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