Drying and gas or vapor contact with solids – Process – With fluid current conveying or suspension of treated material
Reexamination Certificate
2005-11-08
2005-11-08
Bennett, Henry (Department: 3743)
Drying and gas or vapor contact with solids
Process
With fluid current conveying or suspension of treated material
C159S048100
Reexamination Certificate
active
06962006
ABSTRACT:
Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.
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Altreuter David
Bernstein Howard
Chickering, III Donald E.
Keegan Mark
Kopesky Paul
Acusphere, Inc.
Nguyen Camtu
Sutherland & Asbill & Brennan LLP
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