Methods and apparatus for making liposomes containing hydrophobi

Details Methods and apparatus for making liposomes containing hydrophobi Methods and apparatus for making liposomes containing hydrophobi

1996-04-12

1998-07-07

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, 264 46, A61K 9127

Patent

active

057764867

ABSTRACT:
The present application features methods and apparatus for making liposomes containing hydrophobic drugs, with critical, supercritical or near critical fluids. The methods and apparatus combine a phospholipid, a drug, and an aqueous phase, or multilamellar vesicles, with a critical, supercritical or near critical fluid. Upon a reduction in pressure, liposomes are formed.

REFERENCES:
patent: 4608211 (1986-08-01), Handjani
patent: 4971803 (1990-11-01), Li
patent: 5399694 (1995-03-01), Riess

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