Methods and apparatus for intrapulmonary therapy and drug admini

Mechanical guns and projectors – Projectile impelled by user-provided force

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128911, 128912, 12820014, A61M 1600

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active

058030786

ABSTRACT:
An endotracheal catheter assembly and method for deep intrapulmonary, aerosol delivery of liquid drugs and other liquid therapeutic agents. The invention can deliver a bolus dose of liquid drugs into the lungs of a patient which is at least bioequivalent in terms of physiological effect to a similar drug dose delivered intravenously. The catheter assembly includes a first, gas-bearing tube and a second, liquid bearing tube, preferably concentrically nested within the gas-bearing tube. The tubes are inserted in an airway of the patient, preferably by threading the tubes into a lumen of an endotracheal tube, to position a terminal nozzle formed by distal tips of the tubes near a carina of the patient. At the nozzle, the lumen of the first tube has a comparative cross-sectional area relative to that of the second tube's lumen of between about 0.4:1.0 and 4.0:1.0. In operation, high velocity gas is forced from the first tube and impacts liquid expelled from the second tube at a high velocity gas/liquid interface, deforming the liquid into an aerosol and propelling it deep within the lungs of the patient.

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Product Brochure-"Endo-Ject by Autovage", manufactured by Autovage, 1631 Citation Drive, Library, PA (date unknown).
Product Brochure-"Administer RX and CPR simultaneously with EMT", manufactured by Mallinckrodt Medical, Inc., St. Louis, MO, Jan. 1993.

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