Methods and apparatus for image-guided ultrasound delivery of co

Details Methods and apparatus for image-guided ultrasound delivery of co Methods and apparatus for image-guided ultrasound delivery of co

1996-08-21

1998-05-19

Lateef, Marvin M.

Surgery

Truss

Pad

1286532, 1286534, 128654, 12866001, 604 22, A61B 500

Patent

active

057525153

ABSTRACT:
Image-guide methods and apparatus for ultrasound delivery of compounds through the blood-brain barrier to selected locations in the brain target a selected location in the brain and applying ultrasound to effect in the tissues and/or fluids at that location a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging, to confirm the location of that change. A compound, e.g., a neuropharmaceutical, in the patient's bloodstream is delivered to the confirmed location by applying ultrasound to effect opening of the blood-brain barrier at that location and, thereby, to induce uptake of the compound there.

REFERENCES:
patent: 3499437 (1970-03-01), Balamuth
patent: 4303636 (1981-12-01), Gordon
patent: 4315514 (1982-02-01), Drewes et al.
patent: 4923437 (1990-05-01), Gordon
patent: 5059415 (1991-10-01), Neuwelt
patent: 5112596 (1992-05-01), Malfroy-Camine
patent: 5291890 (1994-03-01), Cline et al.
patent: 5307816 (1994-05-01), Hashimoto et al.
patent: 5368032 (1994-11-01), Cline et al.
patent: 5438989 (1995-08-01), Hochman et al.
patent: 5443068 (1995-08-01), Cline et al.
patent: 5465718 (1995-11-01), Hochman et al.
patent: 5485839 (1996-01-01), Aida et al.
patent: 5524620 (1996-06-01), Rosenschein
patent: 5526814 (1996-06-01), Cline et al.
Ryan et al, "Experimental Brain Hyperthermia: Techniques for Heat Delivery and Thermometry", Int J. Radiation Oncology Biol. Phys. vol. 20., pp. 739-750, 1991.
Le Bihan and Turner, "The Capillary Network: A Link between IVIM and Classical Perfusion", Magnetic Resonance in Medicine vol. 27, pp. 171-178, 1992.
Hills and James, "Microbubble Damage to the Blood-Brain Barrier: Relevance to Decompression Sickness", Undersea Biomedical Research, vol. 18, No. 2, pp. 111-116, 1991.
Polyashuk, "Permeability of Hemato-Encephasic Barrier Under the Effect of Supersonic Vibrations", Permeability of Hemato-Encephalic Barrier, p. 415 (parent abstract).
J.T. Patrick et al, "Focal Modification of the Blood-Brain Barrier with High Intensity Ultrasound: Experimental Results and Potential Application for Brain Tumor Therapy" Clinical Research, vol. 35, No. 1, 1987 (Parent abstract).
Mitragotri et al, "Ultrasound-Mediated Transdermal Protein Delivery" Science vol. 269, pp. 850-853, Aug. 11, 1993.
Vykhodtseva et al, "Histologic Effects of High Intensity Pulsed Ultrasound Exposure With Subharmonic Emission in Rabbit Brain In Vivo", Ultrasound in Med. & Biol. vol. 21, Not. 7, pp. 969-979, 1995.
J.T. Patrick et al, "Ultrasound and the Blood-Brain Barrier" In Consensus on Hyperthermia for the 1990s, Ed. H. I. Bicher et al, Plenum Press, New York 1990.

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