Surgery – Liquid medicament atomizer or sprayer
Patent
1997-04-24
2000-08-01
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
12820023, A61M 1100
Patent
active
060951346
ABSTRACT:
Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 .mu.m.
REFERENCES:
patent: 2524590 (1950-10-01), Boe
patent: 2908442 (1959-10-01), Stone
patent: 3159535 (1964-12-01), Sesso et al.
patent: 3694546 (1972-09-01), Roth et al.
patent: 3856185 (1974-12-01), Riccio
patent: 3869070 (1975-03-01), Schmoegner et al.
patent: 4066596 (1978-01-01), Stern
patent: 4161458 (1979-07-01), Kolleth
patent: 4215103 (1980-07-01), Millington
patent: 4536323 (1985-08-01), Stopper
patent: 4582731 (1986-04-01), Smith
patent: 4734227 (1988-03-01), Smith
patent: 4734451 (1988-03-01), Smith
patent: 4790305 (1988-12-01), Zoltan et al.
patent: 4800903 (1989-01-01), Ray et al.
patent: 4814161 (1989-03-01), Jinks et al.
patent: 4845056 (1989-07-01), Yamanis
patent: 4892232 (1990-01-01), Martin
patent: 4895719 (1990-01-01), Radhakrishnan et al.
patent: 4923720 (1990-05-01), Lee et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 4970093 (1990-11-01), Sievers et al.
patent: 5002048 (1991-03-01), Makiej, Jr.
patent: 5013720 (1991-05-01), Whitsett
patent: 5043280 (1991-08-01), Fischer et al.
patent: 5044523 (1991-09-01), McNab
patent: 5056511 (1991-10-01), Ronge
patent: 5115803 (1992-05-01), Sioutas
patent: 5126126 (1992-06-01), Varaprath et al.
patent: 5156747 (1992-10-01), Weber et al.
patent: 5169433 (1992-12-01), Lindsay et al.
patent: 5266205 (1993-11-01), Fulton et al.
patent: 5301664 (1994-04-01), Sievers et al.
patent: 5639441 (1997-06-01), Sievers et al.
patent: 5707634 (1998-01-01), Schmitt
patent: 5770559 (1998-06-01), Manning et al.
European Search Report dated Aug. 27, 1996.
Aphios Corporation, Company Bulletin, Nov. 1993.
Crystal, R.G., "Gene Therapy Strategies for Pulmonary Disease", Am. J. Med., Jun. 1992, 92:6A pp. 44S-52S.
Cygnarowicz, M.L., "Design and Control of a Process to Extract .beta.-Carotene with Supercritical Carbon Dioxide", Biotechnol. Prog. (1990) 6:82-91.
Debenedetti, P.G. et al., "Application of supercritical fluids for the production of sustained delivery devices", J. Controlled Release (1993) 24:27-44.
Debenedetti, P.G. et al., "Rapid Expansion of Supercritical Solutions (RESS): Fundamentals and Applications", Fluid Phase Equilibria (1993) 82:311-321.
Debenedetti, P.G. et al., "Supercritical Fluids: A New Medium for the Formation of Particles of Biomedical Interest", Proc. Int. Symp. Control Rel. Bioact. Mater. (1993) 20:141-142.
Donsi, G. et al., "Micronization by Means of Supercritical Fluids: Possibility of Application to Pharmaceutical Field", Pharm. Acta Helv. (1991) 66:170-173.
Fine, L.W and Beall, H., "Chemistry for Engineers and Scientists", Saunders College Publishing (1990), p. 288.
Foreman, W.T. et al., "Supercritical fluid chromatography with redox chemiluminescence detection", Fresnius Z Anal. Chem. (1988) 330:231-234.
Foreman, W.T. et al., "Supercritical Fluid Chromatography with Sulfur Chemiluminescence Detection", J. Chromatography, (1989) 465:23-33.
Gerrity, T.R. et al., "Calculated depostion of inhaled particles in the airway generations of normal subjects", J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. (1979) 47(4):867-873.
Hannay, J.B. et al, "On the Solubility of Solids in Gases", The Chemical News, (1879) pp. 324-326.
Hickey, A.J., "Lung Depostion and Clearance of Pharmaceutical Aerosols: What Can be Learned from Inhalation Toxicology and Industrial Hygiene?", Aerosol Science and Tech. (1993) 18:290-304.
Ho-Mu Lin et al., "Inactivation of Saccharomyces cerevisiae by supercritical and Subcritical Carbon Dioxide", Biotechnol. Prog. (1992) 8:458-461.
Hunter, B.T. "A Different Kind of Solvent", Consumer's Research (1988) 71:8.
Hybertson, B.M. et al., "Pulmonary Drug Delivery of Fine Aerosol Particles From Supercritical Fluids", J. Aerosol Medicine (1994) 6(4):275-.
Kamihira, M. et al., "Sterilization of Microorganisms with Supercritical Carbon Dioxide", Agric. Biol. Chem., (1987), 51(2):407-412.
Kebarle, P. and Tang, L., "From Ions in Solution to Ions in The Gas Phase", Analytical Chemistry (1993) 65:972-986.
King, M.B. et al., "Mutual Solubilities of Water with Supercritical and Liquid Carbon Dioxide", J. of Supercritical Fluids (1992) 5:296-302.
King, M.B. and Bott, T.R., "Introduction" to Near Critical Solvents (Chapman & Hall pub., London, UK) (1993) pp. 1-33.
Langer, R., "New Methods of Drug Delivery", Articles (Sep. 1990), pp. 1527-1533.
Masayuki Sato, "The Production of Essentially Uniform-Sized Liquid Droplets in Gaseous or Immiscible Liquid Media Under Applied A.C. Potential", J. of Electrostatics, (1984) 15:237-247.
Matson, D.W. et al., "Rapid Expansion of Supercritical Fluid Solutions: Solute Formation of Powders, Thin Films, and Fibers", Ind. Eng. Chem. Res. (1987) 26:2298-2306.
Mohamed, R.S. et al., "Effects of Process Conditions on Crystals Obtained from Supercritical Mixtures", AlChE Journal (1989) 35/2:325-328.
Mohamed, R.S. et al., "Solids Formation After the Expansion of Supercritical Mixtures", Supercritical Fluid Science and Tech. (1989) 355-378.
Morsy, M.A. et al., "Progress Towards Human Gene Therapy", JAMA (1993) 270/19:2338-2345.
Muir, D.C.F. and Verma, D.K., "Occupational and environmental aerosols. Characterization and clinical relevance", Aerosols in Medicine. Principles, Diagnosis and Therapy, Newhous, M.T. and Dolovich, M.B. (eds) (1985), pp. 313-332.
Musser, S.M. and Callery, P.S., "Supercritical Fluid Chromatography/Chemical Ionization/Mass Spectrometry of Some Anticancer Drugs in a Termospray Ion Source", Biomedical and Environ. Mass Spectrometry (1990) 19:348-352.
Newman, S.P. et al., "Therapeutic aerosols 1--Physical and practical considerations", Thorax (1983) 38:881-886.
Newman, S.P., "Aerosol Deposition Considerations in Inhalation Therapy", Chest (1985) 88:152S-160S.
Newman, S.P. et al., "Aerosols in therapy", Aerosols in Medicine. Principles, Diagnosis and Therapy, Moren, F., Newhouse, M.T. and Dolovich, M.B. (eds) (1985), pp. 289-312.
Palmieri, M.D., "An Introduction to Supercritical Fluid Chromatography", J.Chem.Ed. (1988), 65:A254-259.
Rossaint, R. et al., "Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome", N.E. Jrnl. Med. (1993) 328:6:399-405.
Rudolf, R. and Wagner, P.E., "Experiments on Binary Condensational Particle Growth for the Nearly Immiscible System Water--n-Nonane", J. Aerosol. Sci., (1992) 23:S117-S120.
Sadoun, Fr. et al., "Packed-column supercritical fluid chromatography coupled with electrospray ionization mass spectrometry", J. Chromatography (1993) 647:351-359.
Sang-Do Yeo et al., "Formation of Microparticulate Protein Powders Using a Supercritical Fluid Antisolvent", Biotechnology and Bioengineering, (1993) 41:341-346.
Schelkle, M. et al., "Droplet Formation Simulated with an Immiscible Lattice Gas Model", J. Aerosol Sci. (1992) 23:S245-S248.
Swift, David L., "Aerosol characterization and generation", Aerosols in Medicine. Principles, Diagnosis and Therapy, Moren, F., Newhouse, M.T. and Dolovich, M.B. (eds) (1985), pp. 53-76.
Tom, J.W. and Debenedetti, P.G., "Particle Formation with Supercritical Fluids--A Review", J. Aerosol Sci. (1991) 22:555-584.
Tom, J.W. et al., "Applications of Supercritical Fluids in the Controlled Release of Drugs", Supercritical Fluid Engineering Sci., (1993), pp. 238-257.
Tom, J.W. and Debenedetti, P.G., "Formation of Bioerodible Polymeric Microspheres and Microparticles by Rapid Expansion of Supercritical Solutions", Biotechnol. Prog. (1991) 7:403-411.
Tom, J.W. and Debenedetti, P.G., "Precipitation of Poly(Hydroxy Acids) and Coprecipitation of Polymer/Drug Particles by Rapid Expansion of Supercritical Solutions", 104-105.
Washington, N. et al., "Pulmonary Drug Delivery", Physiological Pharmaceu
Karst Uwe
Sievers Robert E.
Lewis Aaron J.
The Board of Regents of the University of Co
LandOfFree
Methods and apparatus for fine particle formation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and apparatus for fine particle formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and apparatus for fine particle formation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-654115