Methods and apparatus for detection of molecular chirality

Chemistry: analytical and immunological testing – Optical result

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S149000, C436S805000, C436S806000, C252S299010, C252S299500

Reexamination Certificate

active

11141433

ABSTRACT:
The disclosure provides methods for the determination of the enantiomeric excess of chiral compounds. The methods involve doping a chiral analyte into an achiral liquid crystal host to form a chiral dopant/host liquid crystal mixture. An electro-optic signature of the mixture is then determined and is used to calculate the enantiomeric excess of the chiral analyte. The disclosure also provides systems for performing the disclosed methods of determining enantiomeric excess.

REFERENCES:
Agarkov et al. (2003) Organic Letters 5(12):2091-2094.
Lochmuller and Ryall (1978) J. of Chromatography 150:511-514.
Mikes et al. (1976) J of Chromatography 122:205-221.
Mikes et al. (1976) J.C.S. Chem. Comm. p. 99-100.
Miller (2004) Acc. Chem. Res. 37:601-610.
Millot et al. (2002) Organic Process Research & Development 6:463-47.
Pirkle et al. (1981).J. Am. Chem. Soc. 103:3964-3966.
Reetz et al. (2000) Chirality 12:479-482.
Reetz. (2000) Angew. Chem.-Int. Edit. 40:284-310.
Reetz et al. (2002) Advanced Synthesis & Catalysis 344:1008-1016.
Reetz and Ruggeberg (2002) Chem. Comm. p. 1428-1429.
Schrader et al. (2002) Can. J. Chem. 80:626-632.
Shen et al. (2001) Isr. J. Chem. 40:313-316.
Stambuli and Hartwig (2003) Current Opinion in Chemical Biology 7:420-426.
Tielmann et al. (2003) Chem.-Eur. J. 9:3882-3887.
Traverse & Snapper (2002) DDT 7:1002-1012.
Whaler and Reymond (2001) Current Opinion in Biotechnology 12:535-544.
Zhu and Anslyn (2004) J. Am. Chem. Soc. 126:3676-3677.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and apparatus for detection of molecular chirality does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and apparatus for detection of molecular chirality, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and apparatus for detection of molecular chirality will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3949838

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.