Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-o
Reexamination Certificate
2005-08-09
2005-08-09
Ludlow, Jan M. (Department: 1743)
Chemistry: analytical and immunological testing
Heterocyclic carbon compound
Hetero-o
C436S056000, C436S086000, C436S150000, C436S164000, C436S172000
Reexamination Certificate
active
06927065
ABSTRACT:
A method for determining the length and velocity of single elongated macromolecules is disclosed. In particular, the present invention relates to methods and apparatus for determining the velocity of elongated polymeric molecules moving relative to one or more detection stations, as well as to methods and apparatus for determining the length of such molecules and the distance between landmarks that may be present on such molecules. The invention makes use of time correlated measurements of signal amplitude profiles that result from interactions between each detection station and portions of each macromolecule.
REFERENCES:
patent: 5079169 (1992-01-01), Chu et al.
patent: 5356776 (1994-10-01), Kambara et al.
patent: 5405747 (1995-04-01), Jett et al.
patent: 5427663 (1995-06-01), Austin et al.
patent: 5538898 (1996-07-01), Wickramasinghe et al.
patent: 5599664 (1997-02-01), Schwartz
patent: 5707797 (1998-01-01), Windle
patent: 5795782 (1998-08-01), Church et al.
patent: 5837115 (1998-11-01), Austin et al.
patent: 5840862 (1998-11-01), Bensimon et al.
patent: 5846724 (1998-12-01), Bensimon et al.
patent: 5846832 (1998-12-01), Oefner et al.
patent: 5851769 (1998-12-01), Gray et al.
patent: 6015714 (2000-01-01), Baldarelli et al.
patent: 6210896 (2001-04-01), Chan
patent: 6263286 (2001-07-01), Gilmanshin et al.
patent: 6355420 (2002-03-01), Chan
patent: 6403311 (2002-06-01), Chan
patent: 6696022 (2004-02-01), Chan et al.
patent: 6762059 (2004-07-01), Chan et al.
patent: 6772070 (2004-08-01), Gilmanshin et al.
patent: 2002/0039737 (2002-04-01), Chan et al.
patent: 2002/0110818 (2002-08-01), Chan
patent: 2002/0119455 (2002-09-01), Chan
patent: 2002/0187508 (2002-12-01), Wong
patent: 2002/0197639 (2002-12-01), Shia et al.
patent: 2003/0059822 (2003-03-01), Chan et al.
patent: 2003/0215864 (2003-11-01), Gilmanshin et al.
patent: 2003/0235854 (2003-12-01), Chan
patent: 2004/0009612 (2004-01-01), Zhao et al.
patent: 2004/0053399 (2004-03-01), Gilmanshin
patent: 2004/0166025 (2004-08-01), Chan et al.
patent: 0391674 (1990-10-01), None
patent: WO 93/22463 (1993-11-01), None
patent: WO 96/29593 (1996-09-01), None
patent: WO 96/30508 (1996-10-01), None
patent: WO 97/06278 (1997-02-01), None
patent: WO 98/10097 (1998-03-01), None
patent: WO 98/35012 (1998-08-01), None
patent: WO 99/05315 (1999-02-01), None
patent: WO 99/24583 (1999-05-01), None
patent: WO 00/06587 (2000-02-01), None
patent: WO 00/09757 (2000-02-01), None
patent: WO 00/60072 (2000-10-01), None
patent: WO 00/60114 (2000-10-01), None
patent: WO 01/13088 (2001-02-01), None
patent: WO 02/099398 (2002-12-01), None
patent: WO 02/101095 (2002-12-01), None
patent: WO 02/101353 (2002-12-01), None
patent: WO 03/025540 (2003-03-01), None
patent: WO 03/091455 (2003-11-01), None
patent: WO 03/100101 (2003-12-01), None
patent: WO 2004/007692 (2004-01-01), None
patent: WO 2004/048514 (2004-06-01), None
patent: WO 2004/066185 (2004-08-01), None
Bakajin et al., Electrohydrodynamic stretching of DNA in confined environments. Phys Rev Lett. Mar. 23, 1998; 80(12): 2737-40.
Fisher88, Fisher Scientific catalog (1988), p. 861.
Austin et al., Stretch genes. Physics Today. 1997; 50:32-8.
Austin et al., Electrophoresis and microlithography, Analysis. 1993; 21: 235-8.
Bensimon et al., Stretching DNA with a receding meniscus: Experiments and models. Phys Rev Lett. Jun 5, 1995;74(23):4754-4757.
Bensimon et al., Alignment and sensitive detection of DNA by a moving interface. Science. Sep 30, 1994;265(5181):2096-8.
Bustamante et al., Entropic elasticity of lambda-phage DNA. Science. Sep 9, 1994;265(5178):1599-600.
Chou et al., A microfabricated device for sizing and sorting DNA molecules. Proc Natl Acad Sci U S A. Jan 5, 1999;96(1):11-3.
Chu et al., Laser manipulation of atoms and particles. Science. 1991; 253: 861-6.
Cluzel et al., DNA: an extensible molecule. Science. Feb. 9, 1996;271(5250):792-4.
Deen et al., Analysis of Transport Phenomena, Oxford University Press; NY. 1998: 275-8.
Duke et al., Microfabricated sieve for the continuous sorting of macromolecules. Phys Rev Lett. 1998; 80: 1552-5.
Ertas et al., Lateral separation of macromolecules and polyelectrolytes in microlithographic arrays. Phys Rev Lett. 1998; 80: 1548-51.
Grandbois et al., How strong is a covalent bond? Science. Mar. 12, 1999;283(5408):1727-30.
Harrison et al., Capillary electrophoresis and sample injection systems integrated on a planar glass chip. Anal Chem. 1992; 64: 1926-32.
Hatfield et al., Dynamic properties of an extended polymer in solution. Phys Rev Lett 1999; 82: 3548-51.
Houseal et al., Real-time imaging of single DNA molecules with fluorescence microscopy. Biophys J. Sep 1989;56(3):507-16.
Jacobson et al., Fused quartz substrates for microchip electrophoresis. Anal Chem. 1995; 67: 2059-63.
Kabata et al., Visualization of single molecules of RNA polymerase sliding along DNA. Science. Dec 3, 1993;262(5139):1561-3.
Kim et al., Intermediates in the folding reactions of small proteins. Annu Rev Biochem. 1990;59:631-60. Review.
Lyon et al., Confinement and detection of single molecules in submicrometer channels. Anal Chem. 1997; 69: 3400-5.
Marko et al., DNA under high tension: overstretching, undertwisting, and relaxation dynamics. Physical Rev. 1998; E27:2134-49.
Marko et al., Stretching DNA. Macromolecules. 1995; 28: 8759-70.
Parra et al., High resolution visual mapping of stretched DNA by fluorescent hybridization. Nat Genet. Sep 1993;5(1):17-21.
Perkins et al., Direct observation of tube-like motion of a single polymer chain. Science. May 6, 1994;264(5160):819-22.
Schmalzing et al., DNA sequencing on micrfabricated electrophoretic devices. Anal Chem. 1998; 70: 2303-10.
Schmalzing et al., DNA typing in thirty seconds with a microfabricated device. Proc Natl Acad Sci U S A. Sep 16, 1997;94(19):10273-8.
Schwartz et al., Ordered restriction maps ofSaccharomyces cerevisiaechromosomes constructed by optical mapping. Science. Oct 1, 1993;262(5130):110-4.
Seiler et al., Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation and separation efficiency. Anal Chem. 1993; 65: 1481-8.
Smith et al., Single-polymer dynamics in steady shear flow. Science. Mar 12, 1999;283(5408):1724-7.
Smith et al., Response of flexible polymers to a sudden elongational flow. Science. Aug 28, 1998;281(5381):1335-40.
Smith et al., Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads. Science. Nov 13, 1992;258(5085):1122-6.
Tan et al., Nanoscale imagin and sensing by near-field optics. inFluorescence Imaging: Spectroscopy and Microscopy.Wang and Herman, Eds., Chemical Analysis Series 137: 407-75.
Volkmuth et al., DNA electrodiffusion in a 2D array of posts. Phys Rev Lett. 1994: 72: 2117-20.
Volkmuth et al., DNA electrophoresis in microlithographic arrays. Nature. Aug 13, 1992;358(6387):600-2.
Washizu et al., Applications of electrostatic stretch-and-positioning of DNA. IEEE Trans Industry Applications. 1990; 26: 1165-72.
Woolley et al., Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips. Proc Natl Acad Sci U S A. Nov 22, 1994;91(24):11348-52.
Zimmermann et al., DNA stretching on functionalized gold surfaces. Nucleic Acids Res. Feb 11, 1994;22(3):492-7.
Akerman, B. et al., “Electrophoretic Orientation of DNA detected by Linear Dichroism Spectroscopy”,J. Chem. Soc. D. Chem. Commun.,1985, pp. 422-423.
Allen, M.J. et al., “Scanning Tunneling Microscope Images of Adenine and Thymine at Atomic Resolution”,Scanning Microscopy,1991, pp. 625-630, vol. 5, No. 3, Scanning Microscopy International, Chicago.
Ambrose, W.P. et al., “Application of Single Molecule Detection to DNA Sequencing and Sizing”,Ber. Bunsenges. Phys. Chem.,1993, pp. 1535-1542, vol. 97, No. 12, VCH Verlagsgesellschaft mbH.
Bello, M.S. et al., “Electroosmosis of polymer in fused silica capillaries”,Electrophoresis,1994, pp. 623-626, vol. 15, VCH Verlagsgesellschaft mbH.
Bezrukov, S.M. et al., “Counting polymers moving through a single ion channel”,Natu
Chan Eugene Y.
Gleich Lance C.
Wellman Parris S.
Ludlow Jan M.
U.S. Genomics, Inc.
Wolf Greenfield & Sacks PC
LandOfFree
Methods and apparatus for characterization of single polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and apparatus for characterization of single polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and apparatus for characterization of single polymers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3458726