Methods and apparatus for analysis of chromatographic migration

Details Methods and apparatus for analysis of chromatographic migration Methods and apparatus for analysis of chromatographic migration

1992-11-19

1993-12-28

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

364497, 210656, 935 77, 935 85, 935 86, 935 87, 2041828, B01D 5702, B01D 1508

Patent

active

052736326

ABSTRACT:
A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.

REFERENCES:
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patent: 4868749 (1989-09-01), Kimura et al.
patent: 4885696 (1989-12-01), Hara
patent: 4941092 (1990-07-01), Hara et al.
patent: 4958281 (1990-09-01), Hara
patent: 4980827 (1990-12-01), Hara
T. Stockham, Jr. et al., "Blind Deconvolution Through Digital Signal Processing," Proceedings. of the IEEE, vol. 63, No. 4, Apr. 1975.

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