Methods and apparatus for amplification of DNA using sonic...

Details Methods and apparatus for amplification of DNA using sonic... Methods and apparatus for amplification of DNA using sonic...

2011-08-09

2011-08-09

Horlick, Kenneth (Department: 1637)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

Reexamination Certificate

active

07993910

ABSTRACT:
Apparatus and methods for amplification of DNA are provided that use sonic energy in place of conventional thermocyclers. In one embodiment, sonic energy is applied to a PCR cocktail to effect dissociation of double stranded DNA into single strands of DNA. A quiescence stage, where no sonic energy is applied, results in amplification of DNA. Repetition of the cycles of application of sonic energy and cessation of application of sonic energy results in DNA amplification.

REFERENCES:
patent: 6719449 (2004-04-01), Laugharn et al.

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