Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Reexamination Certificate
2007-07-16
2010-06-29
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
C564S281000, C568S009000, C424S009100, C424S001650, C424S009420, C424S009500, C424S001890, C424S499000
Reexamination Certificate
active
07744851
ABSTRACT:
The present invention is directed to a method for preparing an anhydrous18F-radiolabeled fluorinating agent by a nucleophilic reaction of a hydrated18F-radiolabeled fluoride ion source with an unsaturated carrier compound; treating the18F-radiolabeled carrier compound to produce a non-aqueous mixture of the18F-radiolabeled carrier compound in a solvent; and reacting the18F-radiolabeled carrier compound with a nucleophilic composition in a nucleophilic reaction to produce an anhydrous18F-radiolabeled fluorinating agent. The present invention is also directed to an anhydrous18F-radiolabeled fluorinating agent comprising the formula [QnM]x+(18F−)x. Additionally, the present invention is directed to an18F-radiolabeled fluorinated radiopharmaceutical or an18F-radiolabeled fluorinated radiotracer prepared by reacting the anhydrous18F-radiolabeled fluorinating agent with a drug intermediate. The present invention is further directed to methods for treating a disease or imaging a subject using an18F-radiolabeled fluorinated radiopharmaceutical or an18F-radiolabeled fluorinated radiotracer.
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DiMagno Stephen Gregory
Sun Haoran
Barker Michael
Board Of Regents Of The University Of Nebraska
Ritchey Steven M.
Saeed Kamal A
Thompson & Coburn LLP
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