Method utilizing purified GP IIb-IIIa to detect the presence of

Details Method utilizing purified GP IIb-IIIa to detect the presence of Method utilizing purified GP IIb-IIIa to detect the presence of

1995-06-05

1998-04-07

Jagannathan, Vasu S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530300, G01N 3368, G01N 3386, C07K 14745, C07K 1475

Patent

active

057363390

ABSTRACT:
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula

REFERENCES:
Fitzgerald et al. 1985 Anal. Biochem 151:169-177.

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