Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-07-15
1995-02-21
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
424 113, 424 165, A61K 31555, A61K 4300
Patent
active
053915470
ABSTRACT:
Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.
REFERENCES:
D. A. Cortese et al., "Hematoporphyrin Derivative in the Detection and Localization of Radiographically Occult Lung Cancer," Am. Rev. Respir. Dis. 126, 1087 (1982).
H. Kato et al., "Early Detection of Lung Cancer by Means of Hematoporphyrin Derivative Fluorescence and Laser Photoradiation," Clin. Chest Med. 6, 237 (1985).
K. B. Patel et al., "Fluorescing Cells In Sputum After Parenteral HPD," Progress in Clinical and Biological Research, vol. 170. D. Doiron and C. Gomer, Eds.; Porphyrin Localization and Treatment of Tumors, 521 (1984).
J. A. Mercer-Smith et al., "The Development of Copper-67-Labeled Porphyrin-Antibody Conjugates," Targeted Diagnosis and Therapy, vol. 1, Antibody-Mediated Delivery Systems; J. D. Rodwell, Ed. (Marcel-Dekker), New York, 1988 pp. 317-352.
J. C. Roberts et al., "Preparation and Characterization of Copper-67 Porphyrin-Antibody Conjugates," J. Immunol. Methods 105, 153 (1987).
G. Firnau et al. ".sup.64 Cu Labelling of Hematoporphyrin Derivative for Noninvasive In-Vivo Measurements of Tumor Uptake," Progress in Clinical and Biological Research, vol. 170, D. Doiron and C. Gomer, Eds; Porphyrin Localization and Treatment of Tumors, pp. 629-636 (1984).
Cole Dean A.
Ellinwood L. Edward
Klein M. Gerard
Moody, III David C.
Freund Samuel M.
Goldberg Jerome D.
University of California Office of Technology Transfer
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