Method to treat Kaposi's sarcoma

Details Method to treat Kaposi's sarcoma Method to treat Kaposi's sarcoma

1991-05-31

1995-11-28

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 44, 530351, A61K 3700

Patent

active

054708249

ABSTRACT:
Substances or agents which diminish the level of IL-6 or its activity in Kaposi's sarcoma-derived cells are useful agents in the treatment of Kaposi's sarcoma. In particular, substances which inhibit the expression of the gene encoding IL-6 or its receptor, or which interfere with the activity of these substances, are useful in the treatment of this condition. In particular, antibodies immunoreactive with these proteins, oligomers which interfere with the production of these materials, or substances which interfere with the activity of other proteins, DNAs or RNAs that regulate the production and activity of IL-6 are thus useful.

REFERENCES:
Rezai et al., J. Cell. Biochem., Suppl. 14D: 176, abstract No. L538 (1990).
Rothenberg et al., J.N.C.I. 81 (20): 1539-1544 (1989).
Ziegler et al., The Lancet (Sep. 15, 1984) p. 641.
Maione et al., Science (1990) 247:77-79.
Sharpe et al. JNCI (1990) 82:848-853.
Brieva et al., Cellular Immunology (1990) 130:303-310.
Nakajima et al., J. Immunol. (1989) 142:531-536.
Breen et al., J. Immunology (1990) 144:480-484.
Miles et al., Proc. Natl. Acad. Sci. (1990) 87:4068-4072.

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