Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1997-08-29
2000-02-15
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241331, 4241411, 4241521, 4241581, 5303871, 5303873, 5303881, 53038823, 5303887, A61K 39395, C07K 1624
Patent
active
060249560
ABSTRACT:
Monoclonal antibodies immunospecific for the neutrophil chemotactic factor, IL-8, have been humanized by reshaping the variable regions to conform more closely to human counterparts. These antibodies are useful in immunoassays to detect IL-8 and as ligands on immunoaffinity columns for purification of human IL-8. In addition, the humanized antibodies have an antiinflammatory effect in patients.
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Matsumoto Yoshihiro
Matsushima Kouji
Sato Koh
Tsuchiya Masayuki
Yamada Yoshiki
Chan Christina Y.
Chugai Pharmaceutical Co., Ltd.
Gambel Phillip
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