Method to stimulate the immune response to specific antigens

Details Method to stimulate the immune response to specific antigens Method to stimulate the immune response to specific antigens

1987-03-13

1990-02-06

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 851, 424 89, 424 91, 424 92, 530350, 530351, 514 21, A61K 3900, A61K 4502, A61K 3702

Patent

active

048987301

ABSTRACT:
Factors secreted in the suppressor cascade are effective in contravening the suppression of the immune system in response to a particular antigen when properly administred. TsF2 factors may administered prior to or contemporaneously with the antigen; TsF1 factors, in order to exhibit this desired effect, must be administered prior to administration of antigen.

REFERENCES:
patent: 4681760 (1987-07-01), Fathman
patent: 4728614 (1988-03-01), Lau
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Green et al., "Hyperimmunity and the Decision to be Intolerent" Annals of the New York Acad. of Science, vol. 392, pp. 318-327, 1982.
Mattingly et al., "Immunologic Suppression After Oral Administration of Antigen", Journal of Immual., vol. 125, No. 3, pp. 1044-1047, 1980.
Suguimura et al., "Antigen-Specific T Cell Suppressor Factor (TSF): Isolation of a CDNA Clone Encoding for a Functional Polypeptide Chain of Phosphorylcholine Specific TSF", Eur. J. Immunol., vol. 15, pp. 873-880, 1985.
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Germain et al., "Antigen Specific T Cell Mediated Suppression", Journal of Immunol., vol. 121, No. 2, pp. 608-612, 1978.
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