Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1989-05-02
1992-07-14
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, 530402, C07K 710, C07K 1300
Patent
active
051304180
ABSTRACT:
Treatment of basic fibroblast growth factor (bFGF) with organic disulfides, preferably glutathione disulfide, or with inorganic compounds of similar function results in a bFGF composition of enhanced stability and resistance to multimerization. The resulting stabilized form mimics the chromatographic behavior of bFGF as isolated from bovine pituitary.
REFERENCES:
patent: 4816561 (1989-03-01), Todaro
Ahmed, The Journal of Biological Chemistry, 250, No. 21, 8477-8482, 1975.
Seno et al., Biochem. Biophys. Res. Comm. (1988) 151:701.
Esch et al., Proc. Natl. Acad. Sci. U.S.A. (1985) 82:6507.
Eagle et al., J. Biol. Chem. (1986) 235(6):1719-1726.
King J. Biol. Chem. (1961) 236(2):PC5.
Huisman et al., J. Lab. Clin. Med. (1962) 60(2)302-319.
Harrap et al., Biochim. Biophys. Acta (1973) 310:104-110.
Isaacs et al., Biochim. Biophys. Acta (1977) 497:192-204.
Mannervitc et al., Biochim. J. (1980) 190:125-130.
Fox et al., J. Biol. Chem. (1988) 263:18452.
Story et al., Biochem. Biophys. Res. Comm. (1987) 142 (3):702-709.
California Biotechnology Inc.
Moezie F. T.
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