Method to separate stereoisomers

Details Method to separate stereoisomers Method to separate stereoisomers

2007-06-12

2007-06-12

Drodge, Joseph (Department: 1723)

Liquid purification or separation

Processes

Chromatography

C514S317000, C546S192000

Reexamination Certificate

active

10772675

ABSTRACT:
A method to resolve the stereoisomers of an optically active compound comprising an amine moiety. The method provides a mixture comprising two stereoisomers of a compound comprising a amine moiety. The method supplies l-fenchyloxyacetic acid, treats the mixture of stereoisomers with that l-fenchyloxyacetic acid, and collects one of those two stereoisomers having greater than a 99 percent enantiomeric excess.

REFERENCES:
patent: 1920160 (1933-07-01), Bruson
patent: 2957880 (1960-10-01), Rometsch
patent: 3848030 (1974-11-01), Viterbo et al.
patent: 6100401 (2000-08-01), Prashad et al.
patent: 6121453 (2000-09-01), Zavareh
patent: 6531489 (2003-03-01), Harris et al.
patent: WO 97/27176 (1997-07-01), None
patent: WO 97/32851 (1997-09-01), None
Approaches to the Preparation of Enantiomerically Pure (2R, 2′R)-(+)-threo-Methylphenidate Hydrochloride, Mahavir Prashad, Adv. Synth. Catal. 2001, 343, No. 5, pp. 379-392, Wiley-Vch Verlag GrmbH 694541 Weinhelm, Germany, 2001, downloaded from the Internet Apr. 28, 2006.
Search for New Drugs, threo AND erythro Isomers of Methyl a-Phenyl-a-(2-Piperidyl)Acetate Hydrochloride, Yakhontov et al, UDC 615.214.31.012.1, published in 1974 by Consultants Bureau, a division of Plenum Publishing Corporation, downloaded from the Internet Apr. 28, 2006.
“1-Menthoxyacetic Acid”, Organic Synthesis, Coll. vol. 3, p. 544, (1955); vol. 23, p. 52 (1943), downloaded from the Internet Apr. 28, 2006.
Factsheet, DBGET Result COMPOUND C02344, DBGET integrated database retreival system, GenomeNet, downloaded from the internet Apr. 28, 2006.

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