Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-12-19
2000-10-17
Eyler, Yvonne
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 721, 435 723, 435 724, 435 74, 435 78, 436 63, G01N 3353, G01N 33367, G01N 33574, G01N 33573
Patent
active
061329789
ABSTRACT:
The present invention relates to methods useful for identifying compounds capable of specifically controlling CD40 regulation of JNK or p38 activity useful for inhibiting immunoglobulin heavy chain class switching, cytokine production and activation of cells involved in an inflammatory response. The present invention also includes kits to perform such assays and methods to control disease related to such responses.
REFERENCES:
patent: 5540926 (1996-07-01), Aruffo et al.
patent: 5605808 (1997-02-01), Karin et al.
patent: 5674492 (1997-10-01), Armitage et al.
Ishizuka et al., "Aggregation of the FceRI on Mast cells stimulates c-Jun Amino-terminal kinase activity" J. Biol. Chem. vol. 271. No. 22. pp. 12762-12766 May 31, 1996.
Bagrodia et al., 1995, J. Biol. Chem, 270:27995-27998.
Faris, et al., 1994, J. Exp. Med., 179:1923-1931.
Gallop, et al., 1994, J. Med. Chem., 37:1233-1251
Han, et al., 1995, Biochim. Biophys. Acta., 1265:224-227.
Kallunki, et al., 1994, Genes and Development, 8:2996-3007.
Kharbanda, et al., 1995, Nature, 376:785-788.
Kramer, et al., 1995, J. Biol. Chem., 46:27395-27398.
Kumar, et al., 1995, J. Biol. Chem., 46:27905-27913.
Landry, et al., 1995, Biochem. Cell. Biol., 73:703-707.
Raingeaud, et al., 1993, J. Biol. Chem., 270:7420-7426.
Raitano, et al., 1995, Proc. Natl. Acad. Sci. USA, 92;11746-11750.
Gelfand Erwin W.
Johnson Gary L.
Eyler Yvonne
National Jewish Medical and Research Center
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