Method to reduce connective tissue destruction

Details Method to reduce connective tissue destruction Method to reduce connective tissue destruction

1992-05-29

1993-11-02

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

514825, A61K 3165

Patent

active

052583716

ABSTRACT:
Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by the following general formula ##STR1## The method is effective in the treatment of various articular diseases characterized by excessive collagen destruction.

REFERENCES:
patent: 4666897 (1987-05-01), Golub et al.
patent: 4704383 (1987-11-01), McNamara et al.
patent: 4925833 (1990-05-01), McNamara et al.
patent: 4935411 (1990-06-01), McNamara et al.
patent: 4935412 (1990-06-01), McNamara et al.
Collier et al., "Evaluation of the Effects of Antiarthritic Drugs on the Secretion of Proteoglycans by Lapine Chondrocytes Using a Novel Assay Procedure", Annals of the Rheumatic Disease 48: 372-381 (1989).
Ramamurthy et al., "Diabetes Increases Collagenase Activity In Extracts of Rat Gingiva and Skin", J. Periodontal Res., 18: 23-30 (1983).
Golub et al., "Minocycline Reduces Gingival Collagenolytic Activity During Diabetes", J. Periodontal Res., 18: 516-526 (1983).
Golub et al., "Tetracyclines Inhibit Tissue Collagenase Activity", J. Periodontal Res., 19: 651-655 (1984).
Yanagimura et al., "Collagenase Activity in Gingival Crevicular Fluid", J. Dent. Res., 68 (Spec. Issue), 1691 (1989).
Golub et al., "Low-dose Doxycycline Therapy: Effect on Gingival and Crevicular Fluid Collagenase Activity in Humans", J. Periodontal Res., 25: 321-330 (1990).
Perry et al., Letters to the Editor, Cornea, 3, 75 (1984).
Perry et al., "Systemic Tetracyclines in the Treatment of Noninfected Corneal Ulcers: A Case Report and Proposed New Mechanism of Action", Ann. Ophthalmol., 17: 742-744 (1985).
Panayi et al., "Minocycline in the Treatment of Patients with Reiter's Syndrome", Clin. Exp. Rheumatol., 7: 100 (1989).
Greenwald et al., "Tetracyclines Inhibit Human Synovial Collagenase In Vivo and In Vitro", J. Rheumatol., 14: 28 (1987).
Breedveld et al., "Minocycline Treatment for Rheumatoid Arthritis: An Open Dose Finding Study", J. Rheumatol., 17: 43 (1990).
Golub et al., "A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity", J. Dent. Res., 66: 1310 (1987).
Rifkin et al., "Effect of a Chemically-Modified Tetracycline (CMT) on Bone Resorption in Organ Culture: Preliminary Observations", J. Cell Biol., 105 Abstracts, Abstr. No. 1223 p. 216a (1987).
Greenwald et al., "Direct Detection of Collagenase and Gelatinase in Periarticular Tissue from Adjuvant Arthritic Rats: Inhibition by Tetracyclines and Potential Amelioration of Bone Destruction", The 36th Annual Meeting Orth Res. Soc., Abstract p. 268 (1990).
Mitscher, "Chemical Transformations of the Tetracycline Family", Chapter 6, The Chemistry of Tetracyclines, Marcel Dekker, Publishers, N.Y. (1978).
Green et al., "Chemistry of the Tetracycline Antibiotics. II. Bromination of Dedimethylaminotetracyclines", J. Am. Chem. Soc., 82: 3946 (1960).
Green et al., "Chemistry of the Tetracycline Antibiotics. III. 12a-Deoxytetracyline", J. Am. Chem. Soc., 82: 3950 (1960).

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