Method to quantify thermal dissipative mechanisms in biomaterial

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7320418, 128630, 374 44, 374169, G01F 168, G06F 1532

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active

048520276

ABSTRACT:
A method for determining the properties of a medium by activating temperature changing means to change the temperature of the medium from a first unperturbed temperature to a second different temperature during a first time period and permitting the temperature to relax to a final unperturbed temperature during a second time period. In a particular embodiment, for example, the intrinsic thermal conductivity and diffusivity of the medium are calculated during a selected portion of the first time period assuming an arbitrary value for the perfusion, and the perfusion of the medium is calculated during a selected portion of the second time period using the calculated intrinsic thermal conductivity and diffusivity. The calculated perfusion is then used to recalculate the intrinsic thermal conductivity and diffusivity during the selected portion of the first time period and the perfusion is then recalculated using such recalculated intrinsic thermal conductivity and diffusivity. The recalculation steps are repeated until each of the recalculated values converge to a substantially non-changing value.

REFERENCES:
patent: Re30317 (1980-07-01), Lubbers et al.
patent: 4059982 (1977-11-01), Bowman
patent: 4538925 (1985-09-01), Zgonik
Bowman et al., "Theory Measurement and Application of Thermal Properties of Biomaterials", Annual Review of Biophysics and Bioengineering, vol. 4, 1975, pp. 43-80.
H. F. Bowman, "Temperature Field Due to a Time Dependent Heat Source of Spherical Geometry in an Infinite Medium", Aug. 1974, pp. 296-299.
H. F. Bowman, "Estimation of Tissue Blood Flow", Heat Transfer in Medicine, Chapter 9, 1984.
Chato, "Method for the Measurement of the Thermal Properties of Biological Materials", 1976, pp. 16-25.

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