Method to protect DNA ends

Details Method to protect DNA ends Method to protect DNA ends

2007-05-01

2007-05-01

Fredman, Jeffrey (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C530S350000

Reexamination Certificate

active

11123701

ABSTRACT:
A method of protecting the 3′ end of a DNA molecule from nuclease damage is disclosed. In one embodiment, the method comprises the step of exposing the DNA molecule to a preparation of DdrA protein.

REFERENCES:
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Miller et al. (“Genetic variability in susceptibility and response to toxicants” Toxicol Lett 2001 Mar. 31;120(1-3):269-80).
Bernstein D, et al., “Crystal structure of theDeinococcus radioduranssingle-stranded DNA-binding protein suggests a mechanism for coping with DNA damage,” Proc. Natl. Acad. Sci. USA 101:8575-8580 (2004).
Clark A, “rec genes and homologous recombination proteins inEscherichia coli,” Biochimie. 73:523-532 (1991).
Harris D, et al., “Preserving genome integrity: the DdrA protein ofDeinococcus radioduransR1,” PLoS Biol. 2:e304 (2004).
Tanaka M, et al., “Analysis ofDeinococcus radiodurans'stranscriptional response to ionzing radiation and desiccation reveals novel proteins that contribute to extreme radioresistance,” Genetics 168:21-33 (2004).

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