Method to produce biotin

Details Method to produce biotin Method to produce biotin

1993-01-22

1995-08-29

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435 691, 435119, 4352523, 43525233, 536 221, 536 231, 536 232, 536 234, 536 237, C12P 1710, C12P 2106, C12N 120, C07H 1900

Patent

active

054459524

ABSTRACT:
The present invention relates to a method to enhance a cell's ability to produce biotin precursors and/or biotin by deregulating at least one enzyme of the fatty acid biosynthetic pathway in the cell, preferably an enzyme that carries out an early step in the pathway. Preferably, the biotin biosynthetic pathway is also deregulated. The invention includes biotin-producing cells in which at least one enzyme of the fatty acid biosynthetic pathway is deregulated, preferably by transforming the cells with nucleic acid sequences encoding at least one of those enzymes; methods to produce such cells; and use of such cells to produce biotin.

REFERENCES:
patent: 5110731 (1992-05-01), Fisher
Eisenberg "Biosynthesis of . . . " E. coli and Salmonella typhimurin pp. 544-549 (1987).
Magnuson et al., "Cloning and nucleotide . . . " FEBS vol. 299, pp. 262-266 (Mar., 1992).
Sabatie et al. "Biotin formation by recombinant Strains . . . " J. of Biotechnology vol. 20, pp. 29-50 (1991).
Rawlings et al. "The gene encoding . . . " J. of Biological Chemistry vol. 267, No. 9 pp. 5751-5754 (Mar. 25, 1992).

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