Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2003-01-14
2009-06-16
Crouch, Deborah (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
C435S325000, C435S375000
Reexamination Certificate
active
07547549
ABSTRACT:
The present invention relates to a method of producing a viable hybrid cell having a single functional mitochondrial population. The method comprises the step of introducing genomic DNA from a mitochondrially depleted donor cell into a recipient cell from which genomic DNA has been removed.
REFERENCES:
patent: WO 01/30980 (2001-05-01), None
patent: WO 01/30980 (2001-05-01), None
Meirelles et al (2001) Complete Replacement of the Mitochondrial Genotype in a Bos indicus calf Reconstituted by Nuclear Transfer to a Bos taurus Oocyte. Genetics. May 2001, vol. 158, pp. 351-356.
Levy et al. Transfer of Chloramphenicol-Resistant Mitochondrial DNA into the Chimeric Mouse. Transgenic Res. 1999, vol. 8, pp. 137-145.
Sims et al. Production of Calves by Transfer to Nuclei from Cultured Inner Cell Mass Cells. Proc. Natl. Acad. Sci. Jun. 1993, vol. 990, pp. 6143-6147.
Hiendleder et al. Transmitochondrial Differences and Varying Levels of Heteroplasmy in Nuclear Transfer Cloned Cattle. Molec. Reprod. Devel. 1999, vol. 54, pp. 24-31.
Keith H.S. Campbell et al., Nuclear Transfer in Practice., Cloning and Stem Cells., 2001, vol. 3, No. 4, p. 201-208, United Kingdom.
Hiroshi Shitara et al., Selective and Continuous Elimination of Mitochondria Microinjected into Mouse Eggs from Spermatids, but not from Liver Cells, Occurs throughout Embryogenesis., Genetics, p. 1277-1284, Nov. 2000.
Jonathan Van Blerkom et al., Mitochondrial Transfer Between Oocytes; Potential Applications of Mitochondrial Donation and the Issue of Heteroplasmy, European Society for Human Reproduction and Embryology, p. 2857-2868, vol. 13 No. 10, Boulder, Co.
Albert S. Jun et al., Use of Transmitochondrial Cybids to Assign a Complex 1 Defect to the Mitochondrial DNA-Encoded NADH Dehydrogenase Subunit 6 Gene Mutation at Nucleotide Pair 14459 that Causes Leber Hereditary Optic Neuropathy and Dystonia. Mar. 1996, p. 771-777, American Society of Biology, Atlanta, GA.
Campbell Keith Henry Stockman
St.John Justin
Crouch Deborah
Fulbright & Jaworski
The University of Birmingham
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