Method to prevent fertilization in mammals by administering a si

Details Method to prevent fertilization in mammals by administering a si Method to prevent fertilization in mammals by administering a si

1996-10-30

1998-04-07

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424450, 424559, 424561, 424812, 514 21, 530853, A61K 3900, A61K 9127, A61K 3554

Patent

active

057361410

ABSTRACT:
A vaccine for the immunocontraception of mammals is described. The vaccine consists of zona pellucida antigens and an adjuvant encapsulated in a liposome delivery system. The liposome delivery system allows for the slow release of antigen resulting in a prolonged immune response. In particular, after a single injection of the vaccine, levels of anti-zona pellucida antibodies were detected for up to 22 months in seals. Thus, the vaccine according to the present invention is effective after a single dose and is therefore very useful in immunocontraceptive protocols.

REFERENCES:
patent: 4053585 (1977-10-01), Allison et al.
patent: 4370349 (1983-01-01), Evans et al.
patent: 4879213 (1989-11-01), Fox et al.
patent: 4996297 (1991-02-01), Dunbar
patent: 5100662 (1992-03-01), Bolcsak et al.
Eldridge, J. L., et al.; Biodegradable Microspheres: Vaccine Delivery System for Oral Immunization; Current Topics in Microbiology and Immunology, 1989, 146, 59-66.
Journal of Biological Chemistry, vol. 262, No. 2, 15 Jan. 1987.
Vaccine Biotechnology, 1989, Academic Press pp. 301-343.
Vaccine Biotechnology, 1989, Academic Press pp. 323-324.
Bowie et al. Science 247:1306-1310 1990.
Sacco et al. Am. J. Reprod. Immunology 21:1-8 1989.
Kumar et al. PNAS 87:1337-1341 1990.
Webster's New World Dictionary, published by the World Publishing Company (1968) see p. 1063.

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