Method to prepare dye-based reference material

Details Method to prepare dye-based reference material Method to prepare dye-based reference material

1997-02-28

1999-04-06

Soderquist, Arlen

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

436 11, 436 15, 436 19, G01N 3100

Patent

active

058917306

ABSTRACT:
Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and may be interpreted by CO-oximeter instrument systems as providing a spectrum substantially equivalent to the spectrum of blood, particularly with regard to hemoglobin and hemoglobin CO-ox fractions. Dye-based reference materials may be formulated to provide CO-ox fractions approximating those seen in a clinical setting, including normal physiological CO-ox fractions. The dye-based reference materials may be combined with other ingredients thus making the materials useful as references for pH and blood gas instruments and/or electrolyte instruments in addition to CO-oximeter instrument systems.

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