Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Nervous system
Patent
1987-05-18
1991-05-21
Stone, Jacqueline M.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Nervous system
514 21, 530300, 530412, 530416, 530417, 530427, 530839, 435 703, 435 4, A61K 3702, A61K 3534
Patent
active
050173758
ABSTRACT:
The present invention is based on the discovery that amyotrophic lateral sclerosis (ALS), Parkinson disease and Alzheimer disease are due to lack of a disorder-specific neurotrophic hormone or factor. Diagnosis is accomplished by assaying factors specific for a particular neuronal network or system; for example, dopamine neutotrophic hormones from striatum or caudate-putamen in the nigrostriatal dopaminergic neural system are used to diagnose and treat parkinsonism. With tissue culture, the presence or absence of spacific neurotrophic factos can be assessed in ALS, parkinsonism, and Alzheimer disease. If there is a deficiency, extracted and purified neurotrophic factors specific to the particular neuronal network or system can be injected into a patient having ALS, Alzheimer disease or parkinsonism for treatment of the disease.
REFERENCES:
patent: 3989819 (1976-11-01), Brockman
Appel, Ann Neurol, 1981, 10:499-505.
Tomozawa and Appel, Society for Neuroscience Abstracts, No. 313.10, vol. II, Part 1; 15th Annual Meeting; Dallas, Texas 10/20/85.
Appel et al; Tropic Factors and Degenerative Neuroligic Disease, May 19-20, 1986, International Conference on Neuroplasticity, Madrid, Spain.
Tomozawa and Appel, Brain Research, 1986, 399:111-124.
Appel Stanley H.
Tomozawa Yasuko
Baylor College of Medicine
Stone Jacqueline M.
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