Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-07-27
1994-04-12
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
12866001, 12866202, A61B 800
Patent
active
053023722
ABSTRACT:
An echo contrast agent for use in echocardiography is disclosed which can be introduced into the body through peripheral venous injection to opacify left ventricle. The echo agent to be injected into the body contains a plurality of gas-in-liquid microbubbles which are smaller than red blood cells and can therefore traverse the pulmonary circulation to reach the left ventricle in substantial quantity to effectuate opacification thereof. The echo contrast agent disclosed in this invention contains: (a) an aqueous solution containing 0.40-0.60 grams of albumin and 4.0-10.0 grams of glucose per 10 ml solution mixed with (b) glycerin. The ratio between (b) and (a) should be no less than 0.050. A method for preparing this echo contrast agent was also disclosed.
REFERENCES:
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4957656 (1990-09-01), Cerny et al.
Feinstein, S. B., et al. Safety and Efficacy of a New Transpulmonary Ultrasound Contrast Agent: Initial Multicenter Clinical Results. J Am Coll Cardiol 1990; 16:316-24.
Smith, M. D., et al. Left Heart Opacification with Peripheral Venous Injection of a New Saccharide Echo Contrast Agent in Dogs. J Am Coll Cardiol 1989; 13:1622-8.
Berwing, K. et al. Echocardiographic imaging of the left ventrical by peripheral intravenous injection of echo contrast agent. Am Heart J 1988; 115:399-408.
Shoa-Lin Lin, et al "Combined Glucose Solution is Better Than Pure Albumin Solution To Opacify the left Ventricle" Abstract of paper presented at 63rd Sci. Sessions of the Am. Heart Asso. (Dec. 13, 1990).
Lin Shoa-Lin
Mou Chung-Yuan
Liauh W. Wayne
National Science Council
Raymond Richard L.
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