Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-29
1995-06-06
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
054223628
ABSTRACT:
A method to inhibit the development of intimal hyperplasia following vascular intervention procedures (angioplasty) is disclosed. The method consists essentially of administering a green porphyrin to the subject concurrent with and following the angioplasty. No purposeful irradiation with light absorbed by the green porphyrin is required or employed in the method.
REFERENCES:
patent: 5116864 (1992-05-01), March et al.
patent: 5283255 (1994-02-01), Levy et al.
patent: 5308608 (1994-05-01), Dolphin et al.
patent: 5308861 (1994-05-01), Aizawa et al.
patent: 5314905 (1994-05-01), Pandey et al.
Sobeh, M. S. et al., Vascular Surgical Society of Great Britain and Ireland Annual General Meeting, London, Nov. 1992.
Sobeh, M. S. et al., 13th Annual American Society of Laser Medicine and Surgery, New Orleans, Apr. 1993.
Copperath, K. et al., Eur. Heart. J. (1989) 10 (Suppl):151.
Asahara, T. et al., Circulation (1992) 86(Suppl) I-846.
Kessel, D. et al., "Porphyrin Accumulation by Atheromatous Plaques of the Aorta", Photochem. Photobiol. (1984) 40:59-61.
Okunaka, T. et al., "Hematoporphyrin Derivative Uptake by Atheroma in Atherosclerotic Rabbits: The Spectra of Fluoresence from Hematoporphyrin Derivatives Demonstrated by an Excimer Dye Laser", Photochem. Photobiol. (1987) 46:769-775.
Spears, J. et al., "Fluorescence of Experimental Atheromatous Plaques with Hematoporphyrin Derivative", J. Clin. Invest. (1983) 71:395-399.
Spokojny, A. et al., "Uptake of Hematoprphyrin Derivative by Atheromatous Plaques: Studies in Human in Vitro and Rabbit in Vivo", J. Am. Col. Cardiol. (1986) 8:1387-1392.
Straight, R. et al., "Porphyrin Retention and Photodynamic Treatment of Diet Induced Atherosclerotic Lesions in Pigs", Photodynamic Therapy of Tumors and Other Diseases, (1985) pp. 349-352.
Dartsch, P. eta l., "Photodynamic Therapy of Vascular Stenoses? III-10", Advances in Laser Medicine 4: Laser Angioplasty II (Biamino, G., et al. eds. 1990) Ecomed Verlagsgesellschaft, Landsberg/Lech, Berlin 77-80.
Dartsch, P. et al., "Differential Effect of Photofrin II on Growth of Human Smooth Muscle Cells from Nonatherosclerotic Arteries and Atheromatous Plaques in Vitro", Atherosclerosis (1990) 10:616-624.
Dartsch, P. et al., "Responses of Cultured Smooth Muscle Cells From Human Nonatherosclerotic Arteries and Primary Stenosing Lesions After Photoradiation: Implications for Photodynamic Therapy of Vascular Stenoses", J. Am. Coll. Cardio. (1990) 15:1545-1550.
Ortu, P. et al., "Photodynamic Therapy of Arteries", Circulation (1992) 85:1189-1196.
Eton, D. et al., "Inhibition of Intimal Hyperplasia by Photodynamic Therapy Using Photofrin", J. Surg. Res. (1992) 53:558-562.
Logan Patricia M.
Vincent G. Michael
Quadra Logic Technologies Inc.
Reamer James H.
LandOfFree
Method to inhibit restenosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method to inhibit restenosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method to inhibit restenosis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-987961