Method to induce cytotoxic T Lymphocytes specific for a broad ar

Details Method to induce cytotoxic T Lymphocytes specific for a broad ar Method to induce cytotoxic T Lymphocytes specific for a broad ar

1993-07-23

1998-01-27

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241841, 4242041, 4242081, 530350, 435 693, 4351723, A61K 3921, A61K 3912, C12P 2106, C07K 100

Patent

active

057119473

ABSTRACT:
The instant invention describes the synthesis of short peptides, corresponding to the amino acid residues of the V3 loop of the gp160 envelope glycoprotein of HIV-1 numbered 315 to 329 by Ratner (Ratner, L. et al., Nature 313, 277 (1985)) in the strain IIIB, wherein the residue corresponding to number 325 in HIV-1 IIIB is substituted by the homologous residue from another clinical isolate or strain. The invention further describes the use of said peptides in pharmaceutical compositions and an immunization protocol which elicits cytotoxic T cells reactive to a broad range of isolates of HIV-1.

REFERENCES:
Buhni, et al, 1994, "Comparative analysis of HIV . . . " Abstract J306, J. Cell. biochem, Suppl. 18B.
Rox, 1994, "No Winners Against AIDS". Biotechnology 12: 128.
Webster's Ninth New Collegiate Dictionary, 1990, pp. 602 and 1301.
Fultz et al, AIDS Volume Research & Chemical Trials, Putney, Bobgnes:Ed, Ny, 1 No. p. 331 Abstract.
Hilleman, Immunol. Ser., 44:605 Abstract 1989.
Eichberg, Int Conf on AIDS, Jun. 20-23, 1990, 6(1):204 abstract #Th.A.338.
Fauci, Ann. Int. Med., (110C5): 373, 1189 Abstract.
Haynes, B.F et al. Science 260: 1279-1286, 1993.
Cease,, K et al. Ann. Rev. Immunol. 12:923-89, 1994.
H. Takahashi et al. Proc. Natl. Acad Sci. USA 85:3105 (1988).
H. Takahasi et al, Science 246:118 (1989).
H. Takahashi et al, J. Exp. Med. 170:2023 (1989).
H. Takahashi et al, Nature 334:873 (1990).

Affiliated with

Also associated with

Rating

Method to induce cytotoxic T Lymphocytes specific for a broad ar does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method to induce cytotoxic T Lymphocytes specific for a broad ar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method to induce cytotoxic T Lymphocytes specific for a broad ar will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-339612