Method to increase the stability of nanocapsules during storage

Details Method to increase the stability of nanocapsules during storage Method to increase the stability of nanocapsules during storage

1997-07-24

1999-03-23

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 46, 4284022, B01J 1304

Patent

active

058854916

ABSTRACT:
Methods of increasing storage stability of lipidic nucleus nanocapsules comprising adding a monosaccharide cryoprotective agent into the aqueous dispersion of the nanocapsules while maintaining gentle stirring until the same dissolves totally. Afterwards, freezing said dispersion thus obtained at a temperature of not less than -40.degree. C. for about 2 to 4 hours, and the eliminating the water by heating progressively to a temperature of about 35.degree. C. at reduced pressure, whereby a stable lyophilized product is obtained. The obtained product can be conveniently reconstituted by adding water or a more complex aqueous solution thereto. The nanocapsules have use in medicine, pharmacy, cosmetics, chemical industry, agriculture, and veterinary science.

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Translation of Auvilliain et al. Jan. 1998 ("Lyophilization De Vecteurs Colloidaux Submiconiques", STP Pharma 5(11) 738-744, Jan. 1998.
"Lyophilization De Vecteurs Colloidaux Submicroniques", By M. Auvillain, G. Cave, H. Fessi and J.P. Devissaguet, In S.T.P. Pharma 5 (11) 738-744, 1989. (with partial translation).
"Hackh's Chemical Dictionary, Fourth Edition", (McGraw-Hill Book Company, NY, NY) pp. 688, 1972 Month unknown.

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