Method to increase the density of antigen on antigen presenting

Details Method to increase the density of antigen on antigen presenting Method to increase the density of antigen on antigen presenting

1996-08-20

1998-11-03

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4242781, 435325, 4353432, 435375, A61K 4500, C07H 2104, C12N 1585

Patent

active

058310681

ABSTRACT:
Disclosed is a method for presenting an antigen in the form of a peptide on the surface of a cell. The method involves inhibiting the activity of an MHC class I pathway-associated component (e.g., a TAP protein or a proteasome or its components) in a cell and contacting the cell with an antigenic peptide to produce a potent antigen presenting cell. The antigen presenting cells of the invention can be administered to a mammal in a method of treating or preventing cancer or infection with a pathogen (e.g., a bacterium or virus). If desired, the antigen presenting cells can be used to stimulate CTL proliferation in vitro, and the resulting effector cells can subsequently be administered to a mammal in a method of therapy.

REFERENCES:
Kuby J. "Immunology." WH Freeman and Company, NY, pp. 239-249, 1994.
Catherine Sibille et al., "LMP2.sup.+ proteasomes are required for the presentation of specific antigens to cytotoxic T Lymphocytes", Current Biology, Aug. 1995, vol. 5, No. 8, pp. 923-930.
Ulrich Steinhoff et al., "Prevention of autoimmune Lysis by T cells with specificity for a heat shock protein by antisense oligonucleotide treatment", Proc. Natl. Acad. Sci., May 1994, vol. 91, No. 5, 5085-5088.
Marja Jaattela et al., "Heat-Shock Proteins Protect Cells from Monocyte Cytotoxicity: Possible Mechanism of Self-Protection", Journal of Experimental Medicine, Jan, 1993, vol. 177, No. 1, pp. 231-236.

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