Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-04-25
2006-04-25
McKelvey, Terry (Department: 1636)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100
Reexamination Certificate
active
07034142
ABSTRACT:
Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat shock response. This allows the development of greatly improved expression systems. The invention is also useful, for example, in the treatment of a patient suffering from a deficiency in the expression of a polypeptide and in the provision of vaccines.
REFERENCES:
patent: 5371015 (1994-12-01), Sanford et al.
patent: 5659122 (1997-08-01), Austin
patent: 5697901 (1997-12-01), Eriksson
patent: WO8700861 (1987-02-01), None
patent: WO 88/00239 (1988-01-01), None
patent: WO9411521 (1994-05-01), None
Verma et al., Nature 389:239-242 (1997).
Palu et al., J. Biotechnol. 68:1-13 (1999).
Luo et al., Nature Biotechnology 18:33-37 (2000).
Fox, ASM News, 66 (2): 1-3 (2000).
Fox, Yahoo! News, Jan. 14, 2003. Accessed Jan. 14, 2003 from http:/
ews.yahoo.com
ews?tmpl=story2&cid=570&u=
m/20030114/sc—nm/health—genetherapy—dc&printer=1.
Bonner et al., “The use of promoter fusions inDrosophilagenetics: isolation of mutations affecting the heat shock response,”Cell37:979-991 (Jul. 1984).
Chiswell et al., “Phage antibodies: will new ‘coliclonal’ antibodies replace monoclonal antibodies?,”Tibtech10:80-84 (Mar. 1992).
DiNocera et al., “Transient expression of genes introduced into cultured cells ofDrosophila,” Proc. Natl. Acad. Sci. USA80:7095-7098 (Dec. 1983).
Geisow, “Improved selection systems for man-made antibodies,”Tibtech10:75-76 (Mar. 1992).
Gray et al., “Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs,”EMBO J.13(16):3882-3891 (1994).
Grosz et al., “Partial and complete sequences of Bovine HSP70-1 and HSP70-2 genes,” Unpublished, Accession U02892, NID g414974.
Hultmark et al., “Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22,”Cell44:429-438 (Feb. 1986).
Hunt et al., “Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines,”Gene87:199-204 (1990).
Illum et al., “Drug delivery,”Current Opinion in Biotechnology2:254-259 (1991).
Ingolia et al., “Sequence of three copies of the gene for the majorDrosophilaheat shock induced protein and their flanking regions,”Cell21:669-679 (Oct. 1980).
Kozac, “Structural features in eukaryotic mRNAs that modulate the initiation of translation,”J. Biol. Chem.266(30):19867-19870 (Oct. 1991).
Langer, “New methods of drug discovery,”Science249:1527-1533 (Sep. 1990).
Lindquist et al., “Selective translation and degradation of heat-shock messenger RNAs inDrosophila,” Enzyme44:147-166 (1990).
McGarry et al., “The preferential translation ofDrosophilahsp70 mRNA requires sequences in the untranslated leader,”Cell42:903-911 (Oct. 1985).
Mestril et al., “Isolation of a novel inducible rat heat-shock protein (HSP70) gene and its expression during ischaemia/hypoxia and heat shock,”Biochem. J.298(pt 3):561-569 (1994).
Morimoto et al., “Organization, nucleotide sequence, and transcription of the chicken HSP70 gene,”J. Biol. Chem.261:12692-12699 (1986).
Myers et al., “Optimal alignments in linear space,”CABIOS4(1):11-17 (1988).
Sachs et al., “Starting at the beginning, middle, and end: translation initiation in eukaryotes,”Cell89(6):831-838 (Jun. 1997).
Sainis et al., “The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family,”FEBS Lett.355(3):282-286 (Dec. 1994).
Schiller et al., “Cis-acting elements involved in the regulated expression of a human HSP70 gene,”J. Miol. Biol.203:97-105 (1988).
Stripecke et al., “Proteins binding to 5′ untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells,”Mol. Cell. Biol.14(9):5898-5909 (Sep. 1994).
Ting et al., “Human gene encoding the 78,000-Dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation,”DNA7(4):275-286 (1988). (GenBank: g183644).
Verme et al., “Gene therapy—promises, problems and prospects,”Nature389(6648):239-242 (Sep. 1997).
Zuker et al., “Well-determined regions in RNA secondary structure prediction: analysis of small subunit ribosomal RNA,”Nucleic Ac. Res.23(14):2791-2798 (1995).
Hess et al., “Sequence and structure determinants ofDrosophilaHsp70 mRNA translation: 5′-UTR secondary structure specifically inhibits heat shock protein mRNA translation”,Nucleic Acids Research24:12 2441-2449 (1996).
Hunt et al., “Inducible expression of cDNAs in a vector based upon the mouse HSP70 heat-shock promoter”,J. Cell. Biochem., Suppl. 12D, 260 , XP000933846 abstract (1988).
Hunt et al., “Human heat shock protein (hsp 70) gene, complete cds”, Accession M11717 (Jul. 1988).
Hunt et al., “Conserved features of eukaryotic hsp-70 genes revealed by comparison with the nucleotide sequence of human hsp-70”,Proc. Natl. Acad. Sci. USA82:19 6455-6459 (1985).
Joshi et al., “5′ untranslated leader sequences of eukaryotic mRNAs encoding heat shock induced proteins”,Nucleic Acids Research23:4 541-549 (1995).
Liarakos et al., “The translation efficiency of ovalbumin mRNA is determined in part by a 5′ -end hairpin structure”,Archives of Biochemistry and Biophysics315:1 54-59 (1994).
Mosely et al., “Heat stress regulates the human 70-kDa heat-shock gene through the 3′ -untranslated region”,American Journal of Physiology264:6 Part 1 L533-L537 (1993).
Pitto et al., “Role of the leader sequence during thermal repression of translation in maize, tobacco, and carrot protoplasts”,Plant Physiology(Rockville) 100:4 1827-1833 (1992).
Coste Herve Jean-Clement
Ellis Jonathan Henry
Conger Michael M.
McKelvey Terry
SmithKline Beecham Corporation
Vogel Nancy T.
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