Method to identify and characterize candidate drugs

Details Method to identify and characterize candidate drugs Method to identify and characterize candidate drugs

1993-09-08

1996-07-30

Lacey, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 793, 436518, 436548, 436809, G01N 3353, G01N 33543

Patent

active

055410707

ABSTRACT:
Methods to identify and characterize a candidate drug by detecting and recording its reactivity with each member of an antibody panel are described. A characteristic profile thus obtained can be compared with the profile obtained in an analogous manner for a ligand known to bind a target so as to identify compounds which also bind the target. A similarity in the analogously obtained characteristic profile of the candidate compound and the known ligand indicated that the candidate will bind a target as well.

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Knox et al. Analytical Biochem 155:92-94 (1986).
Tramontano et al. Science 234:1566-1570 (1986).

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