Method to enhance TPA production

Details Method to enhance TPA production Method to enhance TPA production

1990-02-02

1993-05-11

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352403, 43524031, C12N 964, C12N 510

Patent

active

052100375

ABSTRACT:
A medium supplement which promotes the secretion of tPA from cells producing this protein natively or by virtue of recombinant transformation without the concomitant addition of contaminating proteins is described. Autoclaved brain/heart infusion preparations contribute virtually no extraneous proteins to the medium but greatly enhance the secretion of tPA.

REFERENCES:
patent: 4751084 (1988-06-01), Feder et al.
Chang, Biochim. Biophys. Acta (1986) 823:161-194.
Graham, J. Gen. Virol. (1977) 36:56-72.
Moyer, In Vitro Cellular and Developmental Biology (1977) 23:141-146.
Rhim, Science (1985) 227:1250-1252.
Difco Manual, Dehydrated Culture Media and Reagents for Microbiology, Tenth Ed., pp. 160-164 and 1000, 1984.

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