Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1989-06-23
1990-10-16
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
128653CA, 128654, 436173, 436806, H61K 4900, G01N 3100
Patent
active
049633449
ABSTRACT:
Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid.
REFERENCES:
patent: 3832457 (1974-08-01), Sugimoto et al.
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4125599 (1978-11-01), Wiegert
patent: 4167564 (1979-09-01), Jensen
patent: 4206132 (1980-06-01), Sievers
patent: 4310507 (1982-01-01), Luckey
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4432907 (1984-02-01), Weider et al.
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4478816 (1984-10-01), Ledley et al.
patent: 4615879 (1986-10-01), Runge et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4741900 (1988-05-01), Alvarez et al.
J. F. Desreux, "Nuclear Magnetic Resonance Spectroscopy of Lanthanide Complexes with a Tetraactic Tetraaza Macrocycle, Unusual Conformation Properties," Inorg. Chem., 1980, 19, 1319-1324.
A. E. Martell and M. Calvin, Chemistry of the Metal Chelate Compounds, Prentice-Hall: New York, 1952, pp. ix-xi, 184-184, 207-224, 514-558.
Rubin et al., "The Metabolism of Parenteral Iron Chelates", Biochemical Medicine, vol. 3, pp. 271-288, (1970).
Chemical Abstract, 103:30580b, (Duesler et al.).
The Merck Index, 10th Ed., pp. 578-580, (1983).
Gore et al., "Relaxation Rate Enhancement Observed In Vivo by NMR Imaging" in Partain et al., (eds.), Nuclear Magnetic Resonance (NMR) Imaging, Philadelphia, WB Saunders, Co., 1983.
Chauncey et al., "Tissue Distribution Studies with Radioactive Manganese: A Potential Agent for Myocardial Imaging", Jour. of Nuc. Med., vol. 18, pp. 933-966, 1977.
Herman et al., "Three-Dimensional Display of Nuclear Magnetic Resonance Images", Optical Engineering, vol. 21, No. 5, pp. 923-926, Sep./Oct. 1982.
Frank et al., "Measurement of Proton Nuclear Magnetic Longitudinal Relaxation Times and Water Content in Infracted Canine Myocardium and Induced Pulmonary Injury", Clinical Research, vol. 24, p. 217A, 1976.
P. C. Lauterbur et al., "Augmentation of Tissue Water Proton Spin-Lattice Relaxation Rates by In Vivo Addition of Paramagnetic Ions", Frontiers of Biological Energetics, vol. 1, 752-759, (Encl. 2).
Doyle, F. H., et al., "Relaxation Rate Enhancement Observed In Vivo by NMR Imaging", Proceedings of NMR Imaging Symposium held in Nashville, Tenn., on Oct. 26-27, 1980, and abstracted on Journal of Computer Assisted Tomography, 5 (2) 295-296.
Lauterbur, P. C., "Progress in NMR Zeugmatographic Imaging", Phil. Trans. R. Soc. Lond. B 298, 483-87, (1980).
Pykett, Ian L., "Nuclear Magnetic Resonance, or NMR, Can Reveal the Distribution of Atoms in a Sample of Material. It Can Do the Same in the Body, Generating Images of Internal Structure Without the Use of X Rays", NMR Imaging in Medicine, pp. 78-88.
Brady et al., Radiology, 144, 343, (1982).
Young et al., J. Comput. Tomography 5,6:543-46, (1981).
Morgan et al., "Proton Spin Relaxation in Aqueous Solutions of Paramagnetic Ions. II. Cr.sup.+++, Ni.sup.++, Cu.sup.++, and Gd.sup.+++," The Journal of Chemical Physics, vol. 31, No. 2, pp. 365-368, (Aug. 1959).
Eisinger et al., "Transition Metal Binding in DNA Solutions," The Journal of Chemical Physics, vol. 36, No. 7, pp. 1721-1729, (04/01/1962).
Bertinchamps et al., "Interdependence of Routes Excreting Manganese," Am. J. of Physiology, 211(1), pp. 217-224, (1966).
Catsch, "Probleme de Chelat-Therapie," Naturwissenschaften, pp. 473-474, (1968).
Hosain et al., "Ytterbium-169 Diethylenetriaminepentaacetic Acid Complex," Radiology, 91, pp. 1199-1203, (Dec. 1968).
Davies, "The Clinical Significance of the Essential Biological Metals," Chapter 4--Manganese, pp. 69-80, (London, 1972).
Dwek, "Proton Relaxation Enhancement Probes," Advances in Molecular Relaxation Processes, 4, pp. 1-53, (1972).
Levy et al., "Paramagnetic Relaxation Reagents: Alternatives or Complements to Lanthanide Shift Reagents in Nuclear Magnetic Resonance Spectral Analysis," J. of Am. Chem. Soc., 96:3, pp. 678-681, (02/06/1974).
Derwent Abstract, 61698V/35, (Aug. 22, 1974).
Derwent Abstract, 135A/020, (1975).
Derwent Abstract, 07413x/04, (Jan. 13, 1976).
Ovitt et al., "Improved Instrumentation and Techniques for Non-Invasive Detection, Characterization and Quantification of Arteriosclerosis for Research and Diagnostic Purposes," NTIS No. PB-268,227, dated Apr. 1976.
Chemical Abstract, vol. 87:1879b, Loberg et al., (1977).
Derwent Abstract 84974X/46, (Oct. 29, 1976).
Derwent Abstract, 221/170, (1977).
Elgavish et al. (I), "Aqueous Lanthanide Shift Reagents: 3. Interaction of Ethylenediaminetetraacetate Chelates with Substituted Ammonium Cations," J. Am. Chem. Soc., 99:6, pp. 1762-1765, (03/16/1977).
Ovitt et al., "Improved Instrumentation and Techniques for Non-Invasive Detection, Characterization and Quantification of Atherosclerosis for Research and Diagnostic Purposes," NTIS No. PB-272,617, dated May 1977.
Rote Liste, 1977/78, 12 Antidota, p. 12001.
Lauterbur et al., "Augmentation of Tissue Water Proton Spin-Lattice Relaxation Rates by In Vivo Addition of Paramagnetic Ions," Frontiers of Biological Energetics, vol. 1, pp. 752-759, (1978).
Chemical Abstracts, vol. 91:133246k, Carmona et al., (1979).
Derwent Abstract, 150/429, (1979).
Derwent Abstract, 144/005, (1979).
Derwent Abstract, 78609B/43, (Jan. 30, 1979).
Burton et al., "Proton Relaxation Enhancement (PRE) in Biochemistry: A Critical Survey," Progress in NMR Spectroscopy, vol. 13, pp. 1-45, (1979).
Derwent Abstract, 23893B/12, (Mar. 13, 1979).
Ovitt et al., "Improved Instruments and Techniques for Non-Invasive Detection, Characterization and Quantification of Atherosclerosis for Research and Diagnostic Purposes," NTIS No. PB82-118688, dated Sep. 1, 1979.
Derwent Abstract, 81534B/45, (Sep. 29, 1979).
Lauterbur, "Progress in NMR Zeugmatographic Imaging," Phil. Trans. R. Soc. Lond., B. 289, pp. 483-487, (1980).
Chemical Abstracts, vol. 93:81186k, (1980), Nozaki et al.
Dechter et al., "Aqueous Relaxation Reagents in Nitrogen-15 NMR," Journal of Magnetic Resonance, 39, pp. 207-215, (1980).
Forsberg et al., "Gmelin Handbuch der Anorganischen Chemie: Sc, Y, La-Lu, Rare Earth Elements," 8th Ed., Springer-Verlag, New York, pp. 198-204, (1980).
Derwent Abstract, 05092C/03, (Jan. 1, 1980).
Chemical Abstract, vol. 93:31813s, (Jan. 29, 1980).
Derwent Abstract, 02446D/03, (Jan. 7, 1981).
Chemical Abstract, vol. 95:38681x, Wieder et al., (1981).
Derwent Abstract, 29038D/16, (Apr. 2, 1981).
Derwent Abstract, 34726D/20, (May 6, 1981).
Cotzias, "Manganese versus Magnesium: Why are they so Similar in Vitro and so Different in Vivo?", Brookhaven Nat'l Laboratory, Upton, N.Y., pp. 98-103.
Derwent Abstract, 124/026, (1981).
Tyler et al., "In Vivo Enhancement of Ultrasonic Image Luminence by Aqueous Solutions with High Speed of Sound, Ultrasonic Imaging," pp. 323-329, (1981).
Young et al., "Enhancement of Relaxation Rate with Paramagnetic Contrast Agents in NMR Imaging," Journal of Computer Assisted Tomography, vol. 5, No. 6, pp. 543-546, (1981).
Doyle et al., "Relaxation Rate Enhancement Observed in Vivo by NMR Imaging," Journal of Computer Assisted Tomography, vol. 5, No. 2, pp. 295-296, (1981).
Pykett, "NMR Imaging in Medicine," Scientific American, 246, pp. 78-88, (1982).
Chemical Abstracts, vol. 96:115204u, (1982).
Brady et al., "Proton Nuclear Magnetic Resonance Imaging of Regional Ischemic Canine Hearts: Effect of Parametric Proton Signal Enhancement," Radiology: 144, pp. 343-347, (Jul. 1982).
Mendonca-Dias et al., "Paramagnetic Contrast Agents in Nuclear Magnetic Resonance Medial Imaging," Seminars in Nuclear Medicine, vol. XIII, No. 4, pp. 364-376 (Oct. 1983).
Brasch et al., "Contrast-Enhanced NMR Imaging: Animal Studies Using Gadolinium-DTPA Complex," AJR 142, pp. 625-630
Gries Heinz
Hayden Georg-Alexander
Mutzel Wolfgang
Pfeiffer Heinrich
Rosenberg Douwe
Raymond Richard L.
Schering Aktiengesellschaft
LandOfFree
Method to enhance NMR imaging using chelated paramagnetic ions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method to enhance NMR imaging using chelated paramagnetic ions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method to enhance NMR imaging using chelated paramagnetic ions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-848726