Method to enhance innate immunity defense mechanisms by treatmen

Details Method to enhance innate immunity defense mechanisms by treatmen Method to enhance innate immunity defense mechanisms by treatmen

1998-08-07

2000-11-21

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514 26, A61K 3578

Patent

active

061499129

ABSTRACT:
The present invention relates to a method for enhancing innate immunity defense mechanisms of vertebrate animals including humans. In accordance with the present invention, innate immunity defenses are enhanced by the administration of plant-derived immunomodulators. These plant-derived immunomodulators may be plant tissues, plant extracts containing steroid-like glycoalkaloids, or plant-derived glycoalkaloids. The administration of these immunomodulators significant augments the antimicrobial activities of the innate immune system. The glycoalkaloids useful for the present invention have the formula R--R.sup.1, wherein R is a mono-, di-, tri- or oligo-saccharide which may optionally be modified with pharmacologically acceptable esters or ethers and R.sup.1 is an aglycon or derivative as defined herein. Preferred plant-derived glycoalkaloids include solanine and chaconine.

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