Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-10-29
2009-11-24
Hobbs, Lisa J (Department: 1657)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008100, C530S385000
Reexamination Certificate
active
07622439
ABSTRACT:
The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
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patent: 7211560 (2007-05-01), Looker et al.
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Cabrales et al., “Effects of Extreme Hemodilution with Hemoglobin-based O2Carriers on Microvascular Pressure,” Am. J. Physiol. Heart Circ. Physiol., 2005, vol. 288: No. 5, pp. H2146-H2153.
Winslow et al., “Comparison of PEG-modified Albumin and Hemoglobin in Extreme Hemodilution in the Rat,” J. Appl. Physiol., 2004, vol. 97, No. 4, pp. 1527-1534.
Vandegriff Kim D.
Winslow Robert M.
Axford Laurie A.
Hobbs Lisa J
Sangart, Inc.
The Nath Law Group
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