Method to enhance an immune response of nucleic acid...

Details Method to enhance an immune response of nucleic acid... Method to enhance an immune response of nucleic acid...

2009-09-24

2011-12-13

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S450000, C435S320100, C435S455000, C530S350000, C536S023500

Reexamination Certificate

active

08075896

ABSTRACT:
A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.

REFERENCES:
patent: 5459127 (1995-10-01), Felgner et al.
patent: 6030619 (2000-02-01), Granoff et al.
patent: 6166177 (2000-12-01), Probst et al.
patent: 7008791 (2006-03-01), Gregoriadis et al.
patent: 7285289 (2007-10-01), Nagy et al.
patent: 7381421 (2008-06-01), Gregoriadis
patent: WO-97/28818 (1997-08-01), None
patent: WO-98/10748 (1998-03-01), None
patent: WO-99/30733 (1999-06-01), None
patent: WO-01/41739 (2001-06-01), None
patent: WO-01/56548 (2001-08-01), None
Kato et al., 1991, The Journal of Biological Chemistry, vol. 266, No. 6, pp. 3361-3364.
Shahum et al., 1995, Int. J. Immunopharmac., vol. 17, No. 1, pp. 9-20.
Alvarez-Lajonchere et al., Mem. Inst. Oswaldo Cruz, Rio de Janeiro (2002) 97(1):95-99.
Gregoriadis et al., Journal of Drug Targeting (1996) 3:469-475.
Gregoriadis et al., “Vaccine Entrapment in Liposomes”, Methods: A Companion to Methods in Enzymology, Academic Press Inc., vol. 19, No. 1, Sep. 1999, pp. 156-162.
Gursel et al., Vaccine (1999) 17:1376-1383.
Kirby et al., “Dehydration-Rehydration Vesicles: A Simple Method for High Yield Drug Entrapment in Liposomes”, Biotechnology, Nov. 1984, pp. 465-472.
Klinman et al., Vaccine (1999) 17:19-25.
Lanzavecchia, Nature (1985) 314:537-539.
McCluskie et al., Molecular Medicine (1999) 5:287-300.
Pancer et al., Ann. R. Immunology (2006) doi:10.1146/annurev.immuno1.24.021605.090542.
Potter et al., Indian J. Med. Res. (2004) 119:217-237.
Senior et al., Biochimica et Biophysica Acta (1989) 1003:58-62.
Titti et al., Expert Opin. Emerging Drugs (2007) 12:23-48.
Zadi et al., Journal of Liposome Research (2000) 10:73-80.

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