Method to directly radiolabel antibodies for diagnostic imaging

Details Method to directly radiolabel antibodies for diagnostic imaging Method to directly radiolabel antibodies for diagnostic imaging

1990-10-02

1994-05-03

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

5303915, 530402, A61K 4902, A61K 4300

Patent

active

053086031

ABSTRACT:
The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.

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The invention described herein was made in the course of work under a grant or award from the Department of Energy and an NIH Cancer Research training grant.

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