Method to determine the risk for side effects of an SSRI...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S023500, C536S024310

Reexamination Certificate

active

07083921

ABSTRACT:
A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2Areceptor gene. This provides for a method to improve the treatment of an SSRI responsive disorder and in particular depression.

REFERENCES:
patent: WO 96/17801 (1996-06-01), None
Lucentini et al. The Scientist. Dec. 2004, p. 20.
Oswald et al. European Neuropsychopharmacology. 2003. 13(5):365-368.
Fehr et al. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2001. 25(5): 965-982.
Du et al. “Association of Polymorphism of Serotonin 2A Receptor Gene With Suicidal Ideation in Major Depressive Disorder,”American Journal of Medical Genetics(Neuropsychiatric Genetics) (2000) 96:56-60.
Chen et al. “Lack of Allelic Association Between 102T/C Polymorphism of Serotonin Receptor Type 2A Gene and Schizophrenia in Chinese,”Psychiatric Genetics(1997) 7:35-38.
Murphy et al. “Pharmacogenetics of Antidepressant Medication Intolerance,”Am. J. Psychiatry(2003) 160:10:1830-1835.

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